Evaluating the potentiating effect of amethocaine on tropicamide-induced mydriasis in darkly pigmented irides, using infrared pupillometry.

Ophthalmology and eye diseases Pub Date : 2014-04-08 eCollection Date: 2014-01-01 DOI:10.4137/OED.S13991

Olufunmilola A Ogun, Jeffrey W Oliver, Adeyinka O Ashaye, Benedictus Gk Ajayi

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引用次数: 6

Abstract

Purpose: To determine whether prior instillation of amethocaine would increase the rate and magnitude of tropicamide-induced pupillary dilatation in darkly pigmented irides.

Method: A total of 50 healthy Africans aged 18-40 years, with darkly pigmented irides, received a drop of amethocaine in one eye and a drop of placebo in the contralateral eye, followed by two drops of tropicamide in both eyes. Serial pupil diameters were measured using a monocular infrared video pupillometer. Rate of pupillary dilatation was compared in both eyes. Survival statistics were calculated for the time taken to reach a clinically effective dilatation, clinically effective diameter (CED) of 6.0 mm.

Results: Mean difference in pupil diameters between amethocaine- and placebo-treated eyes was 0.30 ± 0.09 mm (P < 0.002). In all, 62% of amethocaine-treated eyes and only 46% of placebo-treated eyes reached the CED.

Conclusion: We observed a small but statistically significant potentiating effect of a drop of amethocaine on tropicamide-induced dilatation within 20 minutes.

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用红外瞳孔测量法评价阿莫西卡因对热带酰胺诱导的黑色素虹膜丝虫病的增强作用。

目的:确定事先注射阿莫卡因是否会增加热带酰胺引起的瞳孔扩张的速度和程度。方法:50例18-40岁的非洲健康患者，虹膜颜色较深，单眼滴阿莫索卡因，对侧眼滴安慰剂，双眼滴tropicamide。用单目红外视频瞳孔计测量连续瞳孔直径。比较两眼瞳孔扩张率。计算达到临床有效扩张所需时间的生存统计，临床有效直径(CED)为6.0 mm。结果:阿美索卡因组与安慰剂组的瞳孔直径平均差异为0.30±0.09 mm (P < 0.002)。总的来说，接受阿莫西卡因治疗的眼睛中有62%达到了CED，而接受安慰剂治疗的眼睛中只有46%达到了CED。结论:我们观察到滴一滴阿美索卡因在20分钟内对热带胺诱导的扩张有一个小而有统计学意义的增强作用。

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