Associations of common variants in methionine metabolism pathway genes with plasma homocysteine and the risk of type 2 diabetes in Han Chinese.

Q Agricultural and Biological Sciences Journal of Nutrigenetics and Nutrigenomics Pub Date : 2014-01-01 Epub Date: 2014-07-25 DOI:10.1159/000365007

Tao Huang, Jianqin Sun, Yanqiu Chen, Hua Xie, Danfeng Xu, Duo Li

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引用次数: 15

Abstract

Background/aims: An association of genetic variants of homocysteine (Hcy) metabolic genes with type 2 diabetes mellitus (T2DM) has been reported. The objective of the present study was to investigate the relationship between the genetic variants in Hcy metabolism-related genes and plasma Hcy levels and T2DM susceptibility in Han Chinese.

Methods: A total of 774 patients with T2DM and 500 healthy individuals were recruited. Single-nucleotide polymorphism was determined by standard methods.

Results: The Hcy-increasing allele score was positively associated with plasma Hcy levels in both T2DM patients and healthy subjects (r = 0.171 and 0.247, respectively). Subjects with the genotype CC of MTHFR (rs1801131) had a significantly higher likelihood of T2DM compared with subjects with the AA or AA+AC genotypes (OR = 1.93 for CC vs. AA, p = 0.041; OR = 3.13 for CC vs. AA+AC, p = 0.017, respectively). Subjects with the genotype AA of the MTHFD variant (rs2236225) had a significantly lower likelihood of T2DM compared with subjects with the GG or GG+GA genotypes (OR = 0.36 for AA vs. GG, p = 0.027; OR = 0.36 for AA vs. GG+GA, p = 0.017, respectively). In addition, the genotype CT+TT of the PEMT (rs4646356) variants displayed a significant association with an increased risk of T2DM (OR = 1.52 for CT+TT vs. CC, p = 0.042).

Conclusions: MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of T2DM in these Han Chinese.

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蛋氨酸代谢途径基因常见变异与血浆同型半胱氨酸和汉族2型糖尿病风险的关系

背景/目的:同型半胱氨酸(Hcy)代谢基因的遗传变异与2型糖尿病(T2DM)有关联。本研究的目的是探讨Hcy代谢相关基因变异与血浆Hcy水平和2型糖尿病易感性之间的关系。方法:共招募774例T2DM患者和500名健康个体。用标准方法测定单核苷酸多态性。结果:Hcy增高等位基因评分与T2DM患者和健康人血浆Hcy水平呈正相关(r分别为0.171和0.247)。MTHFR (rs1801131)基因型为CC的受试者患T2DM的可能性明显高于AA或AA+AC基因型的受试者(CC vs AA or = 1.93, p = 0.041;CC与AA+AC的OR = 3.13, p = 0.017)。携带MTHFD变异基因型(rs2236225)的AA型受试者与携带GG或GG+GA基因型受试者相比，患T2DM的可能性显著降低(AA对GG的or = 0.36, p = 0.027;AA与GG+GA的OR = 0.36, p = 0.017)。此外，ppt (rs4646356)变异基因型CT+TT与T2DM风险增加显著相关(CT+TT vs. CC OR = 1.52, p = 0.042)。结论:MTHFR rs1801131 C等位基因和ppt rs4646356 T等位基因与汉族T2DM高风险相关。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.