In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring.

Q Agricultural and Biological Sciences Journal of Nutrigenetics and Nutrigenomics Pub Date : 2017-01-01 Epub Date: 2017-04-12 DOI:10.1159/000469663

Hadiza Altine Adamu, Mustapha Umar Imam, Ooi Der-Jiun, Maznah Ismail

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引用次数: 7

Abstract

Background: Numerous studies have reported on the influence of diet on insulin resistance. Our study provides insight into the effect of germinated brown rice (GBR) and γ-aminobutyric acid (GABA) on early environment-driven programming and susceptibility to insulin resistance in rat offspring.

Methods: Male rat offspring from female Sprague-Dawley rats fed with a high-fat diet (HFD) alone, HFD + GBR, or HFD + GABA extract throughout pregnancy and lactation were weaned 4 weeks after delivery and followed up for 8 weeks. A biochemical analysis and an assessment of the hepatic expression of insulin signaling genes were performed.

Results: The results showed that intrauterine exposure to HFD caused metabolic perturbations in rat offspring which gravitated towards insulin resistance even though the rat offspring did not consume an HFD. GBR and GABA attenuated the HFD-induced changes by underlying regulation of the insulin signaling genes.

Conclusions: The results suggest that intake of GBR and GABA during pregnancy and lactation can influence the programming of genes in rat offspring, thereby enhancing insulin sensitivity.

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子宫内暴露于发芽糙米及其GABA提取物可减轻大鼠后代高脂肪饮食诱导的胰岛素抵抗。

背景:大量研究报道了饮食对胰岛素抵抗的影响。我们的研究揭示了发芽糙米(GBR)和γ-氨基丁酸(GABA)对大鼠后代早期环境驱动编程和胰岛素抵抗易感性的影响。方法:雌性Sprague-Dawley大鼠在妊娠和哺乳期分别饲喂高脂饲料(HFD)、HFD + GBR或HFD + GABA提取物的雄性大鼠子代在分娩后4周断奶，随访8周。进行了生化分析和肝脏胰岛素信号基因表达的评估。结果:结果表明，宫内暴露于HFD会引起大鼠后代的代谢紊乱，即使大鼠后代没有摄入HFD，也会导致胰岛素抵抗。GBR和GABA通过潜在的胰岛素信号基因调节来减弱hfd诱导的变化。结论:妊娠和哺乳期摄入GBR和GABA可影响子代大鼠基因编程，从而增强胰岛素敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.