Role of chlorogenic acid and procyanidin in the modification of self-assembled fibrillar gel prepared from tilapia collagen

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2022-12-01 DOI:10.1016/j.polymdegradstab.2022.110177
Xiangsheng An, Shujun Duan, Zhicong Jiang, Sunan Chen, Wenxuan Sun, Xiaoyan Liu, Zhonghao Sun, Yinping Li, Mingyan Yan
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引用次数: 4

Abstract

Collagen fibrillar gels (CFG), formed by self-assembly, displayed similar structure and properties to native tissues. Plant polyphenols showed antioxidant and antibacterial capacity, etc. Previous reports stated introduction of polyphenols could improve the properties of collagen-based material. However, only a few studies were reported on the modification of CFG by polyphenols. In the study, tilapia CFG was cross-linked with chlorogenic acid (CGA) and procyanidin (PC), respectively. The cross-linking conditions were investigated. Results showed PC endowed CFG with higher cross-linking effect at saturation than CGA. ATR-FTIR and XPS displayed there were stronger hydrogen bonds between -OH groups of PC and C = O groups of CFG, but weaker in CGA, confirmed by molecular docking simulation. XRD and SEM indicated PC induced the denser network formed by thinner fibrils, not present in CGA. As a result, water absorption and retention capacity, mechanical properties and enzymatic resistance of gel were improved evidently, whereas thermal stability reduced. Additionally, polyphenol cross-linking granted better antioxidant activity to gel, PC resulting in higher DPPH and PTIO radical scavenging ratio, while CGA showing higher Fe(II) chelation ratio. It also induced better antibacterial activity against Staphylococcus aureus, especially PC cross-linking. The results revealed CFG cross-linked by PC showed better properties compared with CGA, making it have potential application in biomaterials.

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绿原酸和原花青素在罗非鱼胶原蛋白自组装纤维凝胶修饰中的作用
胶原纤维凝胶(CFG)通过自组装形成,具有与天然组织相似的结构和性质。植物多酚具有抗氧化、抗菌等作用。先前的报告指出,多酚的引入可以改善胶原基材料的性能。然而,关于多酚对CFG进行改性的研究报道较少。本研究将罗非鱼CFG分别与绿原酸(CGA)和原花青素(PC)交联。研究了交联条件。结果表明,PC赋能的CFG在饱和状态下具有比CGA更高的交联效应。ATR-FTIR和XPS显示,PC的-OH基团与CFG的C = O基团之间存在较强的氢键,而CGA的氢键较弱。XRD和SEM分析表明,PC诱导了由更薄的原纤维形成的更致密的网络,而CGA没有。结果表明,凝胶的吸水性、保水性能、力学性能和抗酶性能明显提高,但热稳定性降低。此外,多酚交联使凝胶具有较好的抗氧化活性,PC具有较高的DPPH和PTIO自由基清除率,而CGA具有较高的Fe(II)螯合率。对金黄色葡萄球菌具有较好的抗菌活性,尤其是PC交联。结果表明,与CGA相比,PC交联的CFG具有更好的性能,在生物材料中具有潜在的应用前景。
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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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