How Reliable Are Hematological Parameters in Predicting Uncomplicated Plasmodium falciparum Malaria in an Endemic Region?

ISRN tropical medicine Pub Date : 2013-01-01 DOI:10.1155/2013/673798

Haruna Muwonge, Sharif Kikomeko, Larry Fred Sembajjwe, Abdul Seguya, Christine Namugwanya

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引用次数: 39

Abstract

Background: Malaria remains endemic in Sub-Saharan Africa. Hematological changes that occur have been suggested as potential predictors of malaria. This study was aimed at evaluating the diagnostic relevance of hematological parameters in predicting malaria.

Methods: A cross-sectional study involving 370 patients with signs and symptoms of malaria was conducted at Mulago Hospital, Kampala, from May, 2012 to February, 2013. Thin and thick blood films were prepared for each patient and stained with Giemsa to aid the detection of malaria parasites. Patients' hematological parameters were determined.

Results: Out of the 370 patients, 61 (16.5%) had malaria. Significant differences in the hematological parameters between P. falciparum malaria parasitemic patients and nonparasitemic patients were only observed in mean (±SD) of the differential monocyte count (10.89 ± 6.23% versus 8.98 ± 5.02%, p = 0.01) and the platelet count (172.43 (± 80.41) ×10³ cells/μl versus 217.82 ± (95.96) ×10³ cells/μl p = 0.00). The mean (±SD) values of the red blood cell indices (hemoglobin count, MCV, MCH, and MCHC), the differential neutrophil and lymphocyte counts, and the mean platelet volume (MPV) did not significantly differ between the two groups.

Conclusion: Hematological changes are unreliable laboratory indicators of malaria in acute uncomplicated Plasmodium falciparum malaria.

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血液学参数在预测流行地区单纯恶性疟原虫疟疾方面有多可靠?

背景:疟疾在撒哈拉以南非洲仍然流行。发生的血液学变化被认为是疟疾的潜在预测因素。本研究旨在评估血液学参数在预测疟疾中的诊断相关性。方法:对2012年5月至2013年2月在坎帕拉市穆拉戈医院出现疟疾症状和体征的370例患者进行横断面研究。为每位患者制备薄血膜和厚血膜，并用吉姆萨染色以帮助检测疟疾寄生虫。测定患者血液学参数。结果:370例患者中，61例(16.5%)为疟疾。恶性疟原虫疟疾寄生虫患者与非寄生虫患者血液学指标的差异仅在差异单核细胞计数(10.89±6.23% vs 8.98±5.02%，p = 0.01)和血小板计数(172.43(±80.41)×103 cells/μl vs 217.82±(95.96)×103 cells/μl, p = 0.00)的平均值(±SD)上存在显著性差异。两组患者红细胞指数(血红蛋白计数、MCV、MCH、MCHC)、差异中性粒细胞和淋巴细胞计数、平均血小板体积(MPV)的平均值(±SD)无显著差异。结论:血液学变化是急性无并发症恶性疟原虫疟疾不可靠的实验室指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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