Pathogenic microbial amyloids: Their function and the host response.

OA microbiology Pub Date : 2013-12-01
Mc Garcia, Pn Lipke, Sa Klotz
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Abstract

Functional microbial amyloids are ubiquitous in nature and some contribute to the pathogenesis of infectious diseases. Three pathogenic microbial amyloids are compared and their contribution to the disease process explained. The recent demonstration and visualization of fungal amyloid in human invasive candidiasis is discussed. Moreover, the binding of host serum amyloid P component to Candida functional amyloid in invasive human disease is presented in light of its possible role of masking fungi from the host defenses.

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病原微生物淀粉样蛋白:它们的功能和宿主反应。
功能性微生物淀粉样蛋白在自然界中普遍存在,其中一些与传染病的发病机制有关。比较了三种致病微生物淀粉样蛋白,并解释了它们对疾病过程的贡献。本文讨论了近年来真菌淀粉样蛋白在人类侵袭性念珠菌病中的表现和可视化。此外,在侵袭性人类疾病中,宿主血清淀粉样蛋白P组分与念珠菌功能淀粉样蛋白的结合可能在宿主防御中掩盖真菌的作用。
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Pathogenic microbial amyloids: Their function and the host response.
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