[Pleiotropic activity of 3-hydroxy-3-methyl-glutharyl-coenzyme a inhibitors (statins). therapeutic potential in connective tissue diseases ].

Przemysław J Kotyla
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Abstract

3-Hydroxy-3-Methyl-Glutharyl-Coenzyme A reduct- ase inhibitors, known as statins, form a group of chemical compounds that are characterized by the ability to inhibit cholesterol synthesis. Statins have proved their efficacy as potent drugs in the primary and secondary prevention of cardiovascular events. It has also been shown that the thera- peutic effects of statins go beyond reduction of cholesterol level. These properties, which are separate from the influ- ence on cholesterol synthesis, are sometimes called the pleio- tropic effect. This effect comprises immunomodulation, an anti-inflammatory effect, and endothelial function recovery.

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3-羟基-3-甲基-谷胱甘肽辅酶a抑制剂(他汀类药物)的多效性。结缔组织疾病的治疗潜力]。
3-羟基-3-甲基-谷胱甘肽辅酶A还原酶抑制剂,被称为他汀类药物,形成了一组以抑制胆固醇合成能力为特征的化合物。他汀类药物在心血管事件的一级和二级预防中已被证明是有效的药物。研究还表明,他汀类药物的治疗作用不仅仅是降低胆固醇水平。这些特性与对胆固醇合成的影响是分开的,有时被称为多效性效应。这种作用包括免疫调节、抗炎作用和内皮功能恢复。
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