Metabolic factors in diffuse idiopathic skeletal hyperostosis - a review of clinical data.

Q4 Medicine Open Rheumatology Journal Pub Date : 2014-12-19 eCollection Date: 2014-01-01 DOI:10.2174/1874312901408010116

Sruti Pillai, Geoffrey Littlejohn

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引用次数: 77

Abstract

Objectives: We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH.

Method: We identified studies in our personal database and PubMed using the following keywords in various combinations: "diffuse idiopathic skeletal hyperostosis", "ankylosing hyperostosis", "Forestier's disease", "diabetes", "insulin", "obesity", "metabolic", "growth factors", "adipokines", "glucose tolerance" and "chondrocytes".

Results: We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH.

Conclusion: Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.

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弥漫性特发性骨骼肥厚症的代谢因素-临床资料综述。

目的:我们旨在回顾有关代谢因子与弥漫性特发性骨骼肥厚症(DISH)的文献，以评估生长因子与DISH之间的关系。方法:我们使用以下关键词在我们的个人数据库和PubMed中以不同的组合识别研究:“弥漫性特发性骨骼增生”、“强直性骨质增生”、“Forestier’s病”、“糖尿病”、“胰岛素”、“肥胖”、“代谢”、“生长因子”、“脂肪因子”、“葡萄糖耐量”和“软骨细胞”。结果:由于研究方法的可变性，我们无法进行系统评价。我们发现肥胖(尤其是腹部肥胖)、2型糖尿病、葡萄糖不耐受、高胰岛素血症和DISH之间存在正相关。结论:目前的研究表明，某些代谢因素与DISH有关。需要从这些发现和其他新发现的骨骼生长因子中得出更精确的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Rheumatology Journal Medicine-Rheumatology

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0.80

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0.00%

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