Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation.
Zhao-Hua Zhou, Namita Kumari, Jennifer Catalano, Sergei Nekhai, Jasen Wise, Kenneth M Yamada, Subhash Dhawan
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引用次数: 0
Abstract
Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell response inhibited the susceptibility of LNCaP prostate cancer cells to XMRV infection and efficiently retarded the growth of these prostate cancer cells. Our studies delineate a role of HO-1 in the host defense against retroviral infections and may provide novel therapeutic strategies for the treatment of HO-1-sensitive prostate cancer.
期刊介绍：
Computers and Electronics in Agriculture provides international coverage of advances in the development and application of computer hardware, software, electronic instrumentation, and control systems for solving problems in agriculture, including agronomy, horticulture (in both its food and amenity aspects), forestry, aquaculture, and animal/livestock farming. The journal publishes original papers, reviews, and applications notes on topics pertaining to advances in the use of computers or electronics in plant or animal agricultural production, including agricultural soils, water, pests, controlled environments, structures, and wastes, as well as the plants and animals themselves. Post-harvest operations considered part of agriculture (such as drying, storage, logistics, production assessment, trimming and separation of plant and animal material) are also covered. Relevant areas of technology include artificial intelligence, sensors, machine vision, robotics, networking, and simulation modelling.
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