Rapid synthesis and lipase inhibition activity of some new benzimidazole and perimidine derivatives.

Bioorganicheskaia khimiia Pub Date : 2014-05-01
E Menteşe, F Yılmaz, N Karaali, S Ülker, B Kahveci
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Abstract

This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H-NMR and 13C-NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.

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一些新的苯并咪唑和嘧啶衍生物的快速合成及其脂肪酶抑制活性。
本研究利用微波技术合成了一系列新的苯并咪唑、双苯并咪唑和咪啶衍生物,其产率高,反应时间短。新合成化合物的结构经1H-NMR和13C-NMR谱证实。对这些化合物进行了脂肪酶抑制活性筛选。然后,对所有化合物的胰脂肪酶活性进行了评价,结果表明,在不同浓度下,部分2-取代嘧啶、双苯并咪唑和双苯并咪唑衍生物对胰脂肪酶有抑制作用。
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