The Role of Vitamin D in Pediatric Asthma.

Annals of pediatrics & child health Pub Date : 2015-01-01
Selene K Bantz, Zhou Zhu, Tao Zheng
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Abstract

The detrimental effects of vitamin D deficiency in pediatrics have become increasingly apparent and extend beyond skeletal health. Unfortunately, vitamin D deficiency is highly prevalent in atopic pediatric patients, in whom it may disrupt the immune system and induce significant worsening of reactive airways. This review presents evidence that lung development and immune regulatory functions are vitamin D-dependent. We also review clinical studies that explore how vitamin D supplementation may prevent respiratory infections and help improve asthma control, and we elaborate how these effects may vary among populations. We reveal the strong need of screening measures for vitamin D deficiency in high risk pediatric populations, particularly African-Americans, Hispanic-Americans, and children with obesity. Finally, we emphasize that all children, especially those who are asthmatic, should be assessed to ensure adequate intake or supplementation with at least the minimum recommended doses of vitamin D. The simple intervention of vitamin D supplementation may provide significant clinical improvement in atopic disease, especially asthma.

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维生素D在儿童哮喘中的作用。
儿科维生素D缺乏的有害影响已经变得越来越明显,并且超出了骨骼健康的范围。不幸的是,维生素D缺乏症在特应性儿科患者中非常普遍,在他们中,维生素D缺乏症可能会破坏免疫系统,导致反应性气道严重恶化。本文综述了肺部发育和免疫调节功能依赖维生素d的证据。我们还回顾了探索补充维生素D如何预防呼吸道感染和帮助改善哮喘控制的临床研究,并详细说明了这些效果在人群中的差异。我们揭示了对高危儿童人群,特别是非洲裔美国人、西班牙裔美国人和肥胖儿童进行维生素D缺乏筛查的强烈需求。最后,我们强调,所有儿童,特别是哮喘儿童,都应该进行评估,以确保摄入或补充至少最低推荐剂量的维生素D。补充维生素D的简单干预可能会对特应性疾病,特别是哮喘,提供显着的临床改善。
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