Kelei Li, Tao Huang, Ju-Sheng Zheng, Jianqin Sun, Yanqiu Chen, Hua Xie, Danfeng Xu, Jianbo Wan, Duo Li
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引用次数: 5
Abstract
Aims: The present study aimed to investigate the interaction between erythrocyte phospholipid (PL) fatty acids and variants of inflammation-related genes in a Chinese population.
Methods: A total of 622 patients with type 2 diabetes mellitus (T2DM) and 293 healthy subjects were included. Determination of erythrocyte PL fatty acids composition and genotyping of single nucleotide polymorphisms were conducted by standard methods.
Results: A significant interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T allele carriers (TT+CT) had a higher risk of T2DM than noncarriers only when they had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 (95% CI 1.58-4.24; p for interaction=0.005) and 2.49 (95% CI 1.47-4.24; p for interaction=0.021), respectively. A significant interaction of rs8078723 at the intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele carriers (CC+CT) had a lower risk of T2DM than noncarriers only when they had a higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for interaction=0.014).
Conclusions: rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.
目的:本研究旨在探讨中国人群中红细胞磷脂(PL)脂肪酸与炎症相关基因变异之间的相互作用。方法:选取2型糖尿病(T2DM)患者622例，正常人293例。采用标准方法测定红细胞PL脂肪酸组成及单核苷酸多态性基因分型。结果:rs7305618在HNFIA上与C18:2n-6和C20:4n-6存在显著的相互作用，T等位基因携带者(TT+CT)发生T2DM的风险仅在C18:2n-6或C20:4n-6水平较高时高于非携带者，比值比(or)为2.59 (95% CI 1.58-4.24;p为相互作用=0.005)和2.49 (95% CI 1.47-4.24;P为相互作用=0.021)。PSMD3和CSF3基因间区rs8078723与C20:5n-3显著相互作用:C等位基因携带者(CC+CT)只有当C20:5n-3水平较高时，其患T2DM的风险才比非携带者低，OR为0.44 (95% CI 0.26-0.73;P为相互作用=0.014)。结论:rs7305618和rs8078723与中国人群发生T2DM的风险相关，并受红细胞PL脂肪酸组成的调节。
期刊介绍：
The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.
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