Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.

Journal of advanced nutritional and human metabolism Pub Date : 2015-04-26 DOI:10.14800/janhm.784

Martin D Rosenthal, Frederick A Moore

{"title":"Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.","authors":"Martin D Rosenthal, Frederick A Moore","doi":"10.14800/janhm.784","DOIUrl":null,"url":null,"abstract":"<p><p>A new phenotype of multiple organ failure has appeared: Persistent Inflammatory, Immunosuppressed, Catabolic Syndrome (PICS). Comorbidities and age >65 years have been established as the leading risk factors for PICS. As the percentage of elderly people continues to increase the prevalence of PICS in our ICUs will surely grow. Malnutrition (despite appropriate supplementation), recurrent nosocomial infections, frailty, ventilator dependence, and an indolent death depicts the central theme that plagues PICS patients. Aligned with the recently awarded P50 grant by NIGMS entitled, \"PICS: A New Horizon for Surgical Critical Care\", and the University Of Florida's Sepsis and Critical Illness Research Center will investigate the genetic make-up of PICS patients, better understand frailty and the implication in trauma patients, and hopefully elucidate new therapies. Currently, there are no therapies to combat PICS aside from nutritional inference elaborated after reviewing the literature on Burns, Cachexia, and Sarcopenia.</p>","PeriodicalId":90882,"journal":{"name":"Journal of advanced nutritional and human metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2015-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14800/janhm.784","citationCount":"67","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of advanced nutritional and human metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14800/janhm.784","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 67

Abstract

A new phenotype of multiple organ failure has appeared: Persistent Inflammatory, Immunosuppressed, Catabolic Syndrome (PICS). Comorbidities and age >65 years have been established as the leading risk factors for PICS. As the percentage of elderly people continues to increase the prevalence of PICS in our ICUs will surely grow. Malnutrition (despite appropriate supplementation), recurrent nosocomial infections, frailty, ventilator dependence, and an indolent death depicts the central theme that plagues PICS patients. Aligned with the recently awarded P50 grant by NIGMS entitled, "PICS: A New Horizon for Surgical Critical Care", and the University Of Florida's Sepsis and Critical Illness Research Center will investigate the genetic make-up of PICS patients, better understand frailty and the implication in trauma patients, and hopefully elucidate new therapies. Currently, there are no therapies to combat PICS aside from nutritional inference elaborated after reviewing the literature on Burns, Cachexia, and Sarcopenia.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

持续炎症，免疫抑制，分解代谢综合征(PICS):多器官功能衰竭的新表型。

一种新的多器官功能衰竭的表型已经出现:持续性炎症，免疫抑制，分解代谢综合征(PICS)。合并症和年龄>65岁已被确定为PICS的主要危险因素。随着老年人比例的不断增加，重症监护病房的PICS患病率肯定会上升。营养不良(尽管适当补充)、复发性医院感染、虚弱、呼吸机依赖和惰性死亡是困扰PICS患者的中心主题。根据NIGMS最近授予的P50资助，“PICS:外科危重症护理的新视野”，佛罗里达大学败血症和危重症研究中心将调查PICS患者的基因组成，更好地了解虚弱及其对创伤患者的影响，并有望阐明新的治疗方法。目前，除了在回顾烧伤、恶病质和肌肉减少症的文献后阐述的营养推断外，没有治疗PICS的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助