Antioxidant and Anti-Melanogenesis Effects of Colloidal Gold Camellia sinensis L. Extracts.

IF 4.6 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2022-08-30 DOI:10.3390/molecules27175593

Seoyeon Shin, Minjeong Kim, Nuri Song, Sangouk Sun, Joonyong Choi, Kyungmok Park

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引用次数: 3

Abstract

Green tea extract derived from the leaves of Camellia sinensis L. (CS), is a representative beverage with antioxidant, anti-cancer, and anti-viral properties. CS extract is also used in cosmetics. Colloidal gold is generally a sol or colloidal suspension of gold nanoparticles in water. Colloidal gold green tea (CGCS), cultivated as a fertilizer using this colloidal gold solution, contains gold minerals and possesses anti-inflammatory, analgesic, and anti-tumor properties. However, the skin bioactivity of CGCS has not yet been investigated. In this study, we investigated the effect of the CGCS extract on skin whitening. CGCS extract contained high levels of phenols and flavonoids and displayed 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity in a concentration-dependent manner. CGCS extract inhibited melanin synthesis and tyrosinase activity in B16F10 cells more effectively than the CS extract. Moreover, the CGCS extract decreased the expression levels of the melanogenesis-related proteins, tyrosinase, tyrosinase-related proteins (TRPs), and microphthalmia-associated transcription factor (MITF). In conclusion, our study showed that the CGCS extract inhibits the expression of tyrosinase, TRP-1, and TRP-2 via the downregulation of MITF, thereby inhibiting melanin synthesis. Therefore, CGCS can potentially be used as a skin-whitening ingredient in the cosmetic industry.

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茶树胶体金提取物的抗氧化和抗黑色素生成作用。

绿茶提取物是从茶树(Camellia sinensis L.， CS)的叶子中提取的，是一种具有抗氧化、抗癌和抗病毒特性的代表性饮料。CS提取物也用于化妆品。胶体金一般是金纳米颗粒在水中的溶胶或胶体悬浮液。胶体金绿茶(CGCS)是用这种胶体金溶液作为肥料栽培的，它含有金矿物，具有抗炎、镇痛和抗肿瘤的特性。然而，CGCS的皮肤生物活性尚未被研究。在本研究中，我们研究了CGCS提取物对皮肤美白的影响。CGCS提取物含有高水平的酚类和类黄酮，并显示出浓度依赖性的2,2-二苯基-1-苦酰肼(DPPH)自由基清除活性。CGCS提取物对B16F10细胞黑色素合成和酪氨酸酶活性的抑制作用强于CS提取物。此外，CGCS提取物降低了黑素形成相关蛋白、酪氨酸酶、酪氨酸酶相关蛋白(TRPs)和小眼相关转录因子(MITF)的表达水平。综上所述，我们的研究表明，CGCS提取物通过下调MITF抑制酪氨酸酶、TRP-1和TRP-2的表达，从而抑制黑色素的合成。因此，CGCS有可能在化妆品行业中用作皮肤美白成分。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.