Genetic association of ANGPT2 with primary open-angle glaucoma.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2022-10-06 DOI:10.1186/s40662-022-00309-y

Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P Chan, Clement C Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu

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Abstract

Background: To determine the association of the ANGPT2 gene with primary open-angle glaucoma (POAG) in Chinese.

Methods: Six single-nucleotide polymorphisms (SNPs) in ANGPT2 (rs2515487, rs2922869, rs13255574, rs4455855, rs13269021, and rs11775442) were genotyped in a total of 2601 study subjects from two cohorts. One is a Hong Kong Chinese cohort of 484 high tension glaucoma (HTG) and 537 normal tension glaucoma (NTG) patients, and 496 non-glaucoma control subjects. Another cohort is a Shantou Chinese cohort of 403 HTG and 135 NTG patients, and 543 non-glaucoma control subjects. Subgroup analysis by sex was conducted. Outcomes from different cohorts were combined for meta-analysis.

Results: The association of SNP rs11775442 with NTG in the Hong Kong cohort [P = 0.0498, OR = 1.24, 95% confidence interval (CI) 1.00-1.55] after adjusting for age and sex did not reach statistical significance after Bonferroni correction. Other SNPs were not significantly associated with NTG, HTG and POAG in individual cohort or in the combined analyses (P > 0.05). In the subgroup analysis by sex, SNP rs13269021 in the Shantou cohort, but not in the Hong Kong cohort, was significantly associated with NTG in males (P = 0.0081, OR = 1.67, 95% CI: 1.14-2.43) but not in females (P = 0.874). In the combined analyses by sex, no SNPs were significantly associated with NTG, HTG and POAG.

Conclusions: In the subgroup analysis by sex, a significant association was shown in SNP rs13269021 with NTG in Shantou males, but not in Hong Kong males. Further studies are needed to verify the association between ANGPT2 locus (rs13269021) and NTG in Chinese males.

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ANGPT2与原发性开角型青光眼的遗传关系。

背景:探讨ANGPT2基因与中国人原发性开角型青光眼(POAG)的关系。方法:对来自两个队列的2601名研究对象的ANGPT2基因的6个单核苷酸多态性(rs2515487、rs2922869、rs13255574、rs4455855、rs13269021和rs11775442)进行基因分型。一个是香港华人队列，包括484例高压性青光眼(HTG)和537例正常压性青光眼(NTG)患者，以及496例非青光眼对照。另一个队列是汕头的中国队列，包括403例HTG和135例NTG患者，以及543例非青光眼对照。按性别进行亚组分析。不同队列的结果合并进行meta分析。结果:经Bonferroni校正后，香港队列中SNP rs11775442与NTG的相关性[P = 0.0498, OR = 1.24, 95%置信区间(CI) 1.00-1.55]经年龄和性别校正后，无统计学意义。其他snp与NTG、HTG和POAG在个体队列和组合分析中均无显著相关性(P > 0.05)。在按性别划分的亚组分析中，汕头队列的SNP rs13269021与男性NTG显著相关(P = 0.0081, OR = 1.67, 95% CI: 1.14-2.43)，而与女性NTG无显著相关(P = 0.874)。在性别组合分析中，没有snp与NTG、HTG和POAG显著相关。结论:在性别亚组分析中，汕头男性SNP rs13269021与NTG显著相关，但在香港男性中没有。ANGPT2位点(rs13269021)与NTG在中国男性中的相关性有待进一步研究验证。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.