Association between Oxidative Stress Parameters and Hematological Indices in Breast Cancer Patients.

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2022-10-03 eCollection Date: 2022-01-01 DOI:10.1155/2022/1459410

Hiva Danesh, Nasrin Ziamajidi, Seyed Alireza Mesbah-Namin, Nahid Nafisi, Roghayeh Abbasalipourkabir

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引用次数: 10

Abstract

Background: Breast cancer is one of the leading causes of death in women worldwide. This causes an increase in free radicals, resulting in oxidative stress. The aim of this study was to determine the effect of breast cancer on oxidative stress and its relationship with hematological indices.

Methods: This case-control study included 43 women with breast cancer and 37 age-matched healthy controls. Oxidative stress and its correlation with hematological profiles over seven months were evaluated. Finally, the data were compared between the two groups using the t-test and Pearson's test, and the results were analyzed using the SPSS 24 software.

Results: The results revealed that patients with breast cancer had significantly increased hemoglobin (HB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) levels compared with healthy subjects (p < 0.05). In addition, oxidative stress parameters, such as superoxide dismutase (SOD), catalase (CAT), total oxidant status (TOS), and total antioxidant capacity (TAC), were significantly elevated. Glutathione peroxidase (GPX) and malondialdehyde (MDA) were significantly lower in patients with breast cancer than in the control group (p < 0.05). Statistical significance in hematological indices showed a positive or negative correlation with oxidative stress parameters.

Conclusion: Women with breast cancer showed a deranged complete blood count (CBC) pattern compared to healthy individuals.

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乳腺癌患者氧化应激参数与血液学指标的关系

背景:乳腺癌是全世界妇女死亡的主要原因之一。这会导致自由基增加，导致氧化应激。本研究的目的是确定乳腺癌对氧化应激的影响及其与血液指标的关系。方法:本病例对照研究包括43名乳腺癌妇女和37名年龄匹配的健康对照。在7个月内评估氧化应激及其与血液学特征的相关性。最后，采用t检验和Pearson检验对两组数据进行比较，并采用SPSS 24软件对结果进行分析。结果:乳腺癌患者血红蛋白(HB)、红细胞压积(HCT)、平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)水平均显著高于健康人群(p < 0.05)。此外，氧化应激参数，如超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、总氧化状态(TOS)和总抗氧化能力(TAC)显著升高。乳腺癌患者谷胱甘肽过氧化物酶(GPX)、丙二醛(MDA)水平明显低于对照组(p < 0.05)。血液学指标与氧化应激参数呈正相关或负相关，均有统计学意义。结论:与健康个体相比，乳腺癌患者的全血细胞计数(CBC)模式紊乱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Breast Cancer ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

19 weeks

期刊介绍： International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.