{"title":"An Ethical Argument for Ending Human Trials of Amyloid-Lowering Therapies in Alzheimer's Disease.","authors":"Timothy Daly, Karl Herrup, Alberto J Espay","doi":"10.1080/21507740.2022.2129858","DOIUrl":null,"url":null,"abstract":"<p><p>Given the past two decades of over 40 failed trials of amyloid-lowering therapies in Alzheimer's Disease (AD), many of which succeeded in lowering amyloid as designed, we present an ethical argument for emptying the drug pipeline of tests of amyloid-lowering agents so as to end the historical dominance of the amyloid-reducing therapeutic approach in AD.</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"80-81"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJOB Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21507740.2022.2129858","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/10/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0
Abstract
Given the past two decades of over 40 failed trials of amyloid-lowering therapies in Alzheimer's Disease (AD), many of which succeeded in lowering amyloid as designed, we present an ethical argument for emptying the drug pipeline of tests of amyloid-lowering agents so as to end the historical dominance of the amyloid-reducing therapeutic approach in AD.
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