Prognostic Value of Selected Histologic Features for Lung Squamous Cell Carcinoma.

Justine Fan, Samuel M DeFina, He Wang
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Abstract

The recent histologic subtyping of lung adenocarcinoma has demonstrated the prognostic values of histologic patterns in this malignancy. However, the histological features of lung squamous cell carcinoma (SCC) are much less established. This short review discusses several promising histological prognostic markers for SCC, including tumor budding, tumor cell nesting, and the spreading of tumors through air spaces. Wherever appropriate, the biological significance of these morphological features was also discussed. The investigators consider that histological prognostic markers are highly valuable in understanding the cancer biology of SCC, and in guiding clinical treatment. However, larger clinical cohorts are needed to better establish the prognostic values of the aforementioned histological markers. The application of modern technologies, including machine-learning, would make the histological analysis accurate and reproducible.

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肺鳞状细胞癌部分组织学特征的预后价值。
最近肺腺癌的组织学分型已经证明了这种恶性肿瘤的组织学模式的预后价值。然而,肺鳞状细胞癌(SCC)的组织学特征尚不明确。这篇简短的综述讨论了SCC的几个有希望的组织学预后标志物,包括肿瘤出芽、肿瘤细胞筑巢和肿瘤通过空气空间扩散。在适当的地方,还讨论了这些形态特征的生物学意义。研究人员认为,组织学预后标志物在了解鳞状细胞癌的肿瘤生物学和指导临床治疗方面具有很高的价值。然而,需要更大的临床队列来更好地确定上述组织学标记物的预后价值。现代技术的应用,包括机器学习,将使组织学分析准确和可重复。
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