Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Prathvi Shetty, Mohandas Rai, Arun Ravindran, H N Gopalakrishna, Vinitha Ramanath Pai, Bhuvanesh Sukhlal Kalal

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Abstract

Background and objectives: Diabetes mellitus, a global health problem, is associated with metabolic complications such as hyperglycemia, hyperlipidemia, hypertension, cardiovascular diseases, and loss of vision. The present study evaluated the antidiabetic and antihyperlipidemic effects of ethanol extract of Garcinia cambogia (L.) N. Robson (G. cambogia) fruit rind in a streptozotocin-nicotinamide induced diabetic Wistar Rat model.

Materials and methods: Streptozotocin-nicotinamide was injected intraperitoneally to induce diabetes in Wistar rats. Five groups of rats (n=6) - normal control, diabetic, diabetic treated with G. cambogia at 400 mg/kg and 800 mg/kg body weight, and diabetic treated with metformin at 500 mg/kg body weight, were studied. Blood samples were collected after three weeks of treatment. Random blood glucose (RBG), Serum total cholesterol levels (TCL), serum total triglyceride levels (TGL), high-density lipoprotein levels, and body weight were measured.

Results: Although G. cambogia treatment did not have any antidiabetic activity (p>0.05) rind in the streptozotocin-nicotinamide induced diabetic Wistar Rat model, it decreased the serum TCL, and body weight significantly (P<0.05).

Conclusions: Ethanolic extract of G. cambogia fruit rind possesses anti-obesity activity and significantly reduces total cholesterol but does not have antidiabetic activity.

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黄藤提取物对链脲佐菌素-烟酰胺诱导的糖尿病大鼠模型的降血糖和降血脂作用。

背景和目的:糖尿病是一个全球性的健康问题，与代谢并发症如高血糖、高脂血症、高血压、心血管疾病和视力丧失有关。本研究评价了藤黄果乙醇提取物的抗糖尿病和降血脂作用。N. Robson (G. cambogia)果皮在链脲佐菌素-烟酰胺诱导的糖尿病Wistar大鼠模型中的应用。材料与方法:采用Wistar大鼠腹腔注射链脲佐菌素-烟酰胺诱导糖尿病。以正常对照组、糖尿病大鼠、黄芪400 mg/kg、800 mg/kg体重组和二甲双胍500 mg/kg体重组5组大鼠(n=6)为研究对象。治疗三周后采集血样。测定随机血糖(RBG)、血清总胆固醇(TCL)、血清总甘油三酯(TGL)、高密度脂蛋白(高密度脂蛋白)水平和体重。结果:在链脲佐菌素-烟酰胺诱导的糖尿病Wistar大鼠模型中，虽然藤黄果果皮处理无抗糖尿病活性(p>0.05)，但显著降低了血清TCL和体重(p)。结论:藤黄果果皮乙醇提取物具有抗肥胖活性，显著降低总胆固醇，但无抗糖尿病活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.