Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research.

Bacteriophage Pub Date : 2015-05-21 eCollection Date: 2015-04-01 DOI:10.1080/21597081.2015.1050153
Pauline D Scanlan, Angus Buckling, Alex R Hall
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引用次数: 46

Abstract

Antagonistic coevolution between bacteria and phages (reciprocal selection for resistance and infectivity) has been demonstrated in a wide range of natural ecosystems, as well as experimental populations of microbes, yet exploiting knowledge of coevolution for the prophylactic and therapeutic use of phages is under-explored. In this addendum to our recent paper we discuss how real-time coevolution studies using experimental populations of bacteria and phages can provide novel insight into the changes in bacterial phenotypes that result from resistance evolution against coevolving phages, and how this may ultimately improve our understanding of phage therapy and ability to design effective treatments.

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实验进化和细菌耐药性:(co)进化成本和权衡作为噬菌体治疗研究的机会。
细菌和噬菌体之间的拮抗共同进化(抗性和传染性的相互选择)已在广泛的自然生态系统以及实验微生物群体中得到证实,但利用噬菌体的预防和治疗用途的共同进化知识尚未得到充分探索。在我们最近论文的这篇附录中,我们讨论了利用细菌和噬菌体的实验群体进行实时共同进化研究如何为细菌表型的变化提供新的见解,这些变化是由对共同进化的噬菌体的抗性进化引起的,以及这如何最终提高我们对噬菌体治疗的理解和设计有效治疗的能力。
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