Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES Ticks and Tick-borne Diseases Pub Date : 2016-07-01 DOI:10.1016/j.ttbdis.2016.03.019

Andrey V. Barkhash , Vladimir N. Babenko , Mikhail I. Voevoda , Aida G. Romaschenko

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引用次数: 28

Abstract

Genetic predisposition to tick-borne encephalitis (TBE) is rather poorly studied in human populations. Human genes encoding crucial components of antiviral immune response are most likely involved in protective mechanisms against TBE virus. Previously, several single nucleotide polymorphisms (SNPs) located in interleukin 28B (IL28B) and interleukin 10 (IL10) genes were associated with predisposition to chronic hepatitis C (caused by a structurally similar virus from the same Flaviviridae family) in a number of human populations. The aim of the present study was to estimate a possible association of the IL28B gene rs8103142 and rs12980275 SNPs and IL10 gene rs1800872, rs3021094, and rs3024498 SNPs with predisposition to TBE in a Russian population. Genotypic and allelic frequencies for these SNPs were analyzed in 132 non-immunized TBE patients (34 with fever, 60 with meningitis, and 38 with severe central nervous system disease) and compared with the population control (221 Novosibirsk citizens). The results obtained suggest that both studied IL28B gene SNPs, as well as the IL10 gene rs1800872 SNP are associated with predisposition to TBE in Russian population.

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俄罗斯人群中il - 28b和il - 10基因多态性与蜱传脑炎易感性的关系

蜱传脑炎(TBE)的遗传易感性在人群中的研究相当少。人类基因编码抗病毒免疫反应的关键成分，最有可能参与对TBE病毒的保护机制。此前，在许多人群中，位于白细胞介素28B (IL28B)和白细胞介素10 (IL10)基因上的几个单核苷酸多态性(snp)与慢性丙型肝炎(由来自同一黄病毒科的结构相似的病毒引起)的易感性相关。本研究的目的是估计IL28B基因rs8103142和rs12980275 snp以及IL10基因rs1800872、rs3021094和rs3024498 snp与俄罗斯人群中TBE易感性的可能关联。对132例未接种TBE的患者(34例发热、60例脑膜炎、38例重度中枢神经系统疾病)进行基因型和等位基因频率分析，并与人群对照(221例新西伯利亚居民)进行比较。结果表明，在俄罗斯人群中，IL28B基因SNP和IL10基因rs1800872 SNP与TBE易感性相关。

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来源期刊

Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY

CiteScore

6.90

自引率

12.50%

发文量

185

审稿时长

6-12 weeks

期刊介绍： Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.