{"title":"EFFECTS OF GINSENG AND ITS FOUR PURIFED GINSENOSIDES (Rb2, Re, Rg1, Rd) ON HUMAN PANCREATIC ISLET β CELL IN VITRO.","authors":"John Z Q Luo, Joseph W Kim, LuGuang Luo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ginseng has attracted interest because of its potential therapeutic role in diabetes therapy. No direct evidence has shown the effects of ginseng and its components, ginsenosides, on human islet β cell. In this study, we evaluated ginseng extract and ginsenosides (Rb2, Re, Rg1, Rd) on human pancreatic β cell function. The results provide direct evidence that ginseng extract promotes human pancreatic β cell function. Ginsenoside Rb2 increased islet β cell insulin release and promoted β cell migration. Ginsenoside Re had some impact on cell migration, but had no effect on islet function by evaluating insulin release. The other ginsenosides had no effect on insulin release and islet migration. To date, this is the first study that examines the impact of ginsenosides on human pancreatic islets in vitro.</p>","PeriodicalId":91254,"journal":{"name":"European journal pharmaceutical and medical research","volume":"3 1","pages":"110-119"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991827/pdf/nihms772207.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal pharmaceutical and medical research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Ginseng has attracted interest because of its potential therapeutic role in diabetes therapy. No direct evidence has shown the effects of ginseng and its components, ginsenosides, on human islet β cell. In this study, we evaluated ginseng extract and ginsenosides (Rb2, Re, Rg1, Rd) on human pancreatic β cell function. The results provide direct evidence that ginseng extract promotes human pancreatic β cell function. Ginsenoside Rb2 increased islet β cell insulin release and promoted β cell migration. Ginsenoside Re had some impact on cell migration, but had no effect on islet function by evaluating insulin release. The other ginsenosides had no effect on insulin release and islet migration. To date, this is the first study that examines the impact of ginsenosides on human pancreatic islets in vitro.
人参因其在糖尿病治疗中的潜在作用而引起了人们的兴趣。没有直接证据表明人参及其成分人参皂苷对人体胰岛β细胞有影响。在本研究中，我们研究了人参提取物和人参皂苷(Rb2, Re, Rg1, Rd)对人胰腺β细胞功能的影响。结果为人参提取物促进胰腺β细胞功能提供了直接证据。人参皂苷Rb2增加胰岛β细胞胰岛素释放，促进β细胞迁移。人参皂苷Re对细胞迁移有一定影响，但通过评估胰岛素释放对胰岛功能没有影响。其他人参皂苷对胰岛素释放和胰岛迁移没有影响。迄今为止，这是第一次在体外研究人参皂苷对人类胰岛的影响。
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