Blood Donor Screening for West NiIe Virus in Oklahoma and Its Contribution to Disease Surveillance, 2003 -2013.

Walter E Kelley, Kristy Bradley, Ashten Duncan, James Smith
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Abstract

Upon recognition that West Nile virus (WNV) was transmissible by transfusion, universal testing of blood donors by nucleic acid testing (NAT) was initiated in 2003. A retrospective review of 2003-2013 blood donor records and public health surveillance data in Oklahoma was undertaken to determine the percentage of WNV-positive blood donors who developed clinical symptoms post-donation and to examine the incidence and timing of WNV viremic donors in the context of WNV disease reported statewide. Among all WNV NAT-positive blood donors, 19% had self-described symptoms consistent with WNV disease. A viremic blood donor was the seasonal index case of WNV transmission in Oklahoma during one year [2006] of the study period. Blood donors remain an important surveillance component for epidemiologic monitoring of WNV in Oklahoma.

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2003 -2013年俄克拉荷马州西尼埃病毒献血者筛查及其对疾病监测的贡献
在认识到西尼罗病毒(WNV)可通过输血传播后,2003年开始通过核酸检测(NAT)对献血者进行普遍检测。对俄克拉荷马州2003-2013年献血者记录和公共卫生监测数据进行回顾性审查,以确定捐献后出现临床症状的西尼罗河病毒阳性献血者的百分比,并在全州报告的西尼罗河病毒疾病背景下检查西尼罗河病毒血症献血者的发病率和时间。在所有西尼罗河病毒抗体阳性的献血者中,19%的人自述有与西尼罗河病毒疾病一致的症状。在研究期间的一年中[2006年],一名病毒血症献血者是俄克拉荷马州西尼罗河病毒传播的季节性指数病例。献血者仍然是俄克拉荷马州西尼罗河病毒流行病学监测的重要监测组成部分。
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