[Some Approaches to Activation of Antitumor Resistance Mechanisms and Functional Analogs in Categories of Synergetics].

Biofizika Pub Date : 2016-03-01
G v Zhukova, A I Shikhliarova, A V Soldatov, T A Barteneva, V I Petrosian, T N Gudtskova, M I Bragina, O E Polozhentsev, E A Sheiko, N M Maschenko, E A Shirnina, E Yu Zlatnik, T A Kurkina
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Abstract

This paper briefly reviews the ways of activation of the antitumor resistance mechanisms developed on the basis of the concept of the periodic system of general nonspecific adaptational reactions of the body. The principles of the formation of effective influences by electromagnetic radiation using biologically active substances are described. A comparison of the criteria and conceptions of the theory of adaptational reactions to some concepts and categories of synergetics is made. The features of dynamics of the studied parameters upon effective influences are considered. Antistress nature of the systemic effects of ferromagnetic nanoparticles on tumor bearing animals is shown. The, possible mechanisms of regression of large tumor under the influence of two different factors--modulated electromagnetic radiation and magnetite nanoparticles--are discussed. The cases of a change of the order parameter in connection with the development of antistress areactivity and regression of experimental tumors under the influence of the combined electromagnetic impact are analyzed.

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[协同学中抗肿瘤耐药机制的激活和功能类似物的一些方法]。
本文以机体一般非特异性适应反应周期系统的概念为基础,简要综述了激活抗肿瘤耐药机制的途径。介绍了利用生物活性物质形成电磁辐射有效影响的原理。将适应性反应理论的标准和概念与协同学的一些概念和范畴进行了比较。考虑了有效影响下所研究参数的动力学特性。显示了铁磁纳米颗粒对荷瘤动物的全身效应的抗应激性质。本文讨论了在调制电磁辐射和磁铁矿纳米颗粒两种不同因素影响下大肿瘤消退的可能机制。分析了在联合电磁冲击作用下,序参量的变化与抗应激反应活性的发展和实验肿瘤的消退有关的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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