The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology.

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI:10.1155/2016/6351473
Stephen Paul Fitzgerald, Nigel Geoffrey Bean
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引用次数: 25

Abstract

Context. Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies. The reasons for the similarities and differences between the curves describing these relationships are unresolved. Methods. We subjected the curve, derived from empiric data, describing the TSH suppression response to T4, and the more mathematically derived curve describing the T4 response to TSH, to the different possible models of population variation. The implied consequences of these in terms of generating a population distribution of T4/TSH equilibrium points (a "population curve") were generated and compared to the empiric population curve. The physiological responses to primary hypothyroidism and hyperthyroidism were incorporated into the analysis. Conclusions. Though the population curve shows a similarly inverse relationship, it is describing a different relationship than the curve describing the suppression of TSH by T4. The population curve is consistent with the physiological studies of the TSH response to T4 and implies a greater interindividual variation in the positive thyroid T4 response to TSH than in the central inhibitory TSH response to T4. The population curve in the dysthyroid states is consistent with known physiological responses to these states.

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人群T4/TSH设定点数据与T4/TSH生理的关系
上下文。T4/TSH设定点分布的人群研究表明,T4和TSH之间的负相关关系比生理学研究表明的更为复杂。描述这些关系的曲线之间的相似和不同的原因尚未解决。方法。我们将从经验数据得出的描述T4对TSH抑制反应的曲线,以及更数学化的描述T4对TSH反应的曲线,应用于不同可能的种群变异模型。在生成T4/TSH平衡点(“人口曲线”)的人口分布方面,这些隐含的后果被生成并与经验人口曲线进行比较。对原发性甲状腺功能减退和甲状腺功能亢进的生理反应纳入分析。结论。尽管总体曲线显示出类似的反比关系,但它描述的关系与描述T4抑制TSH的曲线不同。人群曲线与TSH对T4反应的生理研究相一致,表明甲状腺T4对TSH的阳性反应比中枢抑制TSH对T4的反应有更大的个体差异。甲状腺功能障碍状态的人口曲线与已知的对这些状态的生理反应是一致的。
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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