Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis

Q Medicine Birth defects research. Part A, Clinical and molecular teratology Pub Date : 2016-05-13 DOI:10.1002/bdra.23511

Li Wang, Shaofang Shangguan, Shaoyan Chang, Xin Yu, Zhen Wang, Xiaolin Lu, Lihua Wu, Ting Zhang

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引用次数: 13

Abstract

Background

The methylenetetrahydrofolate reductase (MTHFR) polymorphism is a risk factor for neural tube defects. C677T and A1298C MTHFR polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein.

Methods

A meta-analysis was conducted to assess the association between MTHFR C677T/A1298C genotypes and global genomic methylation.

Results

Eleven studies met the inclusion criteria. Of these, 10 were performed on C677T MTHFR genotypes and 6 were performed on A1298C MTHFR genotypes. Our results did not indicate any correlation between global methylation and MTHFR A1298C, C677T polymorphisms.

Conclusion

The results of our study provide evidence to assess the global methylation modification alterations of MTHFR polymorphisms among individuals. However, our data did not found any conceivable proof supporting the hypothesis that common variant of MTHFR A1298C, C677T contributes to methylation modification. Birth Defects Research (Part A) 106:667–674, 2016. © 2016 Wiley Periodicals, Inc.

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确定亚甲基四氢叶酸还原酶(MTHFR)基因多态性与基因组DNA甲基化水平之间的关系:一项荟萃分析

背景亚甲基四氢叶酸还原酶(MTHFR)多态性是神经管缺陷的危险因素。C677T和A1298C MTHFR多态性产生一种与叶酸相关的一碳代谢减少的酶，这与DNA和蛋白质的异常甲基化修饰有关。方法采用meta分析评估MTHFR C677T/A1298C基因型与全球基因组甲基化的关系。结果11项研究符合纳入标准。其中C677T MTHFR基因型10例，A1298C MTHFR基因型6例。我们的研究结果没有显示全局甲基化与MTHFR A1298C, C677T多态性之间的任何相关性。结论本研究结果为评估个体间MTHFR多态性的整体甲基化修饰改变提供了依据。然而，我们的数据没有发现任何可想象的证据支持MTHFR A1298C, C677T共同变异有助于甲基化修饰的假设。出生缺陷研究(分册)，2016.(06):667 - 674。©2016 Wiley期刊公司

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