Wound healing activity of aqueous dispersion of fullerene C60 produced by “green technology”

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-01-01 DOI:10.1016/j.nano.2022.102619

N.N. Shershakova PhD , S.M. Andreev PhD , A.A. Tomchuk MSc , E.A. Makarova MSc , A.A. Nikonova PhD , E.A. Turetskiy PhD , O.A. Petukhova MSc , O.Y. Kamyshnikov MSc , O.I. Ivankov PhD , O.A. Kyzyma DSc , O.V. Tomchuk PhD , M.V. Avdeev DSc , A.S. Dvornikov DSc, MD , D.A. Kudlay DSc, MD , M.R. Khaitov DSc, MD

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引用次数: 6

Abstract

In addition to exhibited antioxidant and anti-inflammatory activity, fullerene C60 is a promising wound healing agent. An important stage in the production of fullerene-based ointments is the stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).

As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution nanoclusters have a size of 6 nm and are assembled into agglomerates which reach a size of 150 nm.

The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.

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“绿色技术”制备的富勒烯C60水分散体的伤口愈合活性

富勒烯C60除了具有抗氧化和抗炎活性外，还是一种很有前途的伤口愈合剂。在富勒烯软膏的生产中，一个重要的阶段是保证水相富勒烯分散体(AFD)的稳定性，使其具有最小尺寸的胶体富勒烯聚集体和足够高的浓度。为了达到这些参数，采用了富勒烯C60的切向流过滤(“绿色技术”)。通过小角中子散射和动态光散射估计，具有窄尺寸分布的纯化afd的纳米团簇尺寸为6 nm，并被组装成团聚体，团聚体尺寸达到150 nm。采用动物创面模型研究了AFD的再生能力。这项研究首次表明，富勒烯为基础的组合物刺激各种来源的伤口愈合。我们认为AFD创面愈合活性的机制与芳烃受体和巨噬细胞活性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.