The safety assessment of saffron (Crocus sativus L.) on sympathovagal balance and heart rate variability; a comparison with amiodarone

Siyavash Joukar, Mohammad-Moein Dehesh
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引用次数: 11

Abstract

  1. Dry stigmas of the Crocus sativus L. (Saffron) are well known in world as a popular flavouring and therapeutic agent. The anxiolytic, antidepressant, anticonvulsant and antiarrhythmic effects of saffron suggest that it may affect the autonomic control of the heart.
  2. This study assessed its safety on cardiac sympathovagal balance and heart rate variability in rat.
  3. Experimental groups were control, Saf50, Saf100, Saf200 (received saffron at dosages of 50 and 100 and 200 mg/kg/d, orally, respectively) and Amio (received 30 mg/mL/kg/d of amiodarone, orally, for 7 days) groups. On day 8, the frequency domain and time domain indices of animals' electrocardiograms were calculated.
  4. The heart rate decreased and RR interval increased in Saf200 and Amio groups (P<.05 vs other groups). Square root of the mean squared differences of successive RR intervals enhanced in all treated groups, however, was only significant in Amio group (P<.05). The SD1/SD2 ratio was higher in Saf200 and Amio groups. Both low-frequency (LF) and high-frequency (HF) parameters were higher, and the LF/HF ratio was non-significantly lower in treated groups.
  5. The findings suggest that saffron not only has no harmful effect on activity of cardiac autonomic nervous system, but it may improve the stability of heart sympathovagal balance in normal rat.
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藏红花(Crocus sativus L.)对交感迷走神经平衡和心率变异性的安全性评价与胺碘酮的比较
藏红花(Crocus sativus L.,藏红花)的干柱头作为一种流行的调味品和治疗剂在世界上是众所周知的。藏红花的抗焦虑、抗抑郁、抗惊厥和抗心律失常作用表明,它可能影响心脏的自主控制。本研究评估其对大鼠心脏交感迷走神经平衡和心率变异性的安全性。试验组分为对照组、Saf50组、Saf100组、Saf200组(分别给予藏红花50、100、200 mg/kg/d,口服)和Amio组(给予胺碘酮30 mg/mL/kg/d,口服,连用7 d)。第8天,计算动物心电图频域和时域指数。Saf200组和Amio组大鼠心率降低,RR间期增加(p < 0.05)。05 vs其他组)。所有治疗组连续RR区间的均方根差均增加,但只有Amio组显著(p < 0.05)。Saf200组和Amio组的SD1/SD2比值较高。治疗组的低频(LF)和高频(HF)参数均升高,LF/HF比值无显著降低。研究结果表明,藏红花不仅对心脏自主神经系统的活性无不良影响,而且可能提高正常大鼠心脏交感迷走神经平衡的稳定性。
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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