Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.

IF 4.7 2区心理学 Q1 BEHAVIORAL SCIENCES Behavioral and Brain Functions Pub Date : 2016-06-17 DOI:10.1186/s12993-016-0102-3

Jacqueline S Womersley, Bafokeng Mpeta, Jacqueline J Dimatelis, Lauriston A Kellaway, Dan J Stein, Vivienne A Russell

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Abstract

Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains.

Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats.

Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.

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在自发性高血压大鼠注意力缺陷/多动症模型中，发育压力引起对甲基苯丙胺的偏好。

背景：发育压力被认为会与遗传易感性相互作用，从而增加罹患药物使用障碍的风险。在这里，我们利用注意力缺陷/多动症动物模型自发性高血压大鼠与 Wistar Kyoto 和 Sprague-Dawley 比较品系的甲基苯丙胺偏好行为替代物，研究了母体分离诱导的发育压力的影响：结果：使用条件性位置偏好范式分析结果显示，自发性高血压大鼠的母体分离会诱发其对甲基苯丙胺相关隔室的偏好，因此存在明显的品系 × 压力交互作用。母体分离增加了自发性高血压大鼠和 Sprague-Dawley 大鼠对甲基苯丙胺运动刺激效应的行为敏感性，但对 Wistar Kyoto 大鼠没有影响：我们的研究结果表明，注意力缺陷/多动症遗传大鼠模型中的发育压力可能会导致药物使用障碍的发生。

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来源期刊

Behavioral and Brain Functions 医学-行为科学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.