{"title":"[PERSISTENT DRUG-INDUCED LIVER DAMAGES IN PATIENTS WITH PULMONARY TUBERCULOSIS].","authors":"","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The authors discuss the problem associated with the severe, persistent course of drug-induced liver disease slightly responsive to traditional treatment in patients receiving antituberculous therapy. The objective of the study was to reveal the essence and causes of drug-induced liver damage characterized by its severe, persistent course, evident clinical and laboratory manifestations, and a weak response to traditional therapy and to develop diagnostic principles. The severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy was shown to be caused by a few competitive pathological processes occurring in the liver rather than failures in the therapeutic and diagnostic process. Prognostic criteria for the severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy have been developed. A diagnostic algorithm is proposed.</p>","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tuberculosis and Lung Diseases","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The authors discuss the problem associated with the severe, persistent course of drug-induced liver disease slightly responsive to traditional treatment in patients receiving antituberculous therapy. The objective of the study was to reveal the essence and causes of drug-induced liver damage characterized by its severe, persistent course, evident clinical and laboratory manifestations, and a weak response to traditional therapy and to develop diagnostic principles. The severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy was shown to be caused by a few competitive pathological processes occurring in the liver rather than failures in the therapeutic and diagnostic process. Prognostic criteria for the severe, persistent course of drug-induced liver disease slightly responsive to traditional therapy have been developed. A diagnostic algorithm is proposed.
期刊介绍:
The Journal is aimed for professional development of researchers, doctors, teachers of medical universities and training institutions. The Journal focuses on the presentation of results of research, case studies, issues of differential diagnostics and treatment in the phthisiologist’s practice, national programs on tuberculosis control in the Russian Federation, WHO strategies, discussion of prevention issues to stop transmission of TB/HIVco-infection, and extrapulmonary tuberculosis.