Emotional prosody processing in autism spectrum disorder.

IF 3.1 2区医学 Q2 NEUROSCIENCES Social cognitive and affective neuroscience Pub Date : 2017-02-01 DOI:10.1093/scan/nsw118

Gabriela Rosenblau, Dorit Kliemann, Isabel Dziobek, Hauke R Heekeren

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引用次数: 39

Abstract

Individuals with Autism Spectrum Disorder (ASD) are characterized by severe deficits in social communication, whereby the nature of their impairments in emotional prosody processing have yet to be specified. Here, we investigated emotional prosody processing in individuals with ASD and controls with novel, lifelike behavioral and neuroimaging paradigms. Compared to controls, individuals with ASD showed reduced emotional prosody recognition accuracy on a behavioral task. On the neural level, individuals with ASD displayed reduced activity of the STS, insula and amygdala for complex vs basic emotions compared to controls. Moreover, the coupling between the STS and amygdala for complex vs basic emotions was reduced in the ASD group. Finally, groups differed with respect to the relationship between brain activity and behavioral performance. Brain activity during emotional prosody processing was more strongly related to prosody recognition accuracy in ASD participants. In contrast, the coupling between STS and anterior cingulate cortex (ACC) activity predicted behavioral task performance more strongly in the control group. These results provide evidence for aberrant emotional prosody processing of individuals with ASD. They suggest that the differences in the relationship between the neural and behavioral level of individuals with ASD may account for their observed deficits in social communication.

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自闭症谱系障碍的情绪韵律加工。

自闭症谱系障碍(Autism Spectrum Disorder, ASD)以严重的社会沟通缺陷为特征，其情绪韵律加工缺陷的性质尚未明确。在这里，我们用新颖、逼真的行为和神经成像范式研究了ASD个体和对照组的情绪韵律加工。与对照组相比，患有ASD的个体在行为任务中表现出情绪韵律识别的准确性降低。在神经层面上，与对照组相比，ASD患者的STS、脑岛和杏仁核在复杂情绪和基本情绪方面的活动减少。此外，在ASD组中，STS和杏仁核之间对复杂情绪和基本情绪的耦合减少。最后，各组在大脑活动和行为表现之间的关系方面存在差异。情绪韵律加工过程中的大脑活动与ASD参与者的韵律识别准确性有更强的相关性。相比之下，STS和前扣带皮层(ACC)活动之间的耦合在对照组中更能预测行为任务的表现。这些结果为ASD个体的异常情绪韵律加工提供了证据。他们认为，自闭症个体的神经和行为水平之间关系的差异可能解释了他们在社会沟通中观察到的缺陷。

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来源期刊

Social cognitive and affective neuroscience 医学-神经科学

CiteScore

6.80

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.