Luciana Bento-de-Souza , Jefferson R. Victor , Luiz C. Bento-de-Souza , Magaly Arrais-Santos , Andréia C. Rangel-Santos , Érica Pereira-Costa , Elaine Raniero-Fernandes , Maria I. Seixas-Duarte , João B. Oliveira-Filho , Alberto J. Silva Duarte
{"title":"Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus","authors":"Luciana Bento-de-Souza , Jefferson R. Victor , Luiz C. Bento-de-Souza , Magaly Arrais-Santos , Andréia C. Rangel-Santos , Érica Pereira-Costa , Elaine Raniero-Fernandes , Maria I. Seixas-Duarte , João B. Oliveira-Filho , Alberto J. Silva Duarte","doi":"10.1016/j.rinim.2016.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.</p></div>","PeriodicalId":89845,"journal":{"name":"Results in immunology","volume":"6 ","pages":"Pages 15-20"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rinim.2016.04.001","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in immunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211283916300041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
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