Endometriosis origin from primordial germ cells.

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Organogenesis Pub Date : 2017-07-03 Epub Date: 2017-05-09 DOI:10.1080/15476278.2017.1323162
Zograb Makiyan
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引用次数: 27

Abstract

Endometriosis is defined by the presence of endometrial ectopia. Multiple hypotheses have been postulated to explain the etiology of endometriosis to understand various clinical evidences. The etiology of endometriosis is still unclear.The primary question to understanding the etiology of endometrial ectopia (endometriosis) is determining the origin of eutopic (normally cited) endometrium.According to the new theory, primordial germ cells migrate from hypoblast (yolk sac close to the allantois) to the gonadal ridges. The gonadal ridges which composed of primordial germ cells derive to the: eutopic endometrium, ovary, ovarian ligament and ligamentum teres uteri.There are 2 principal processes in uterine organogenesis: the intersection of gonadal ridges with mesonephral ducts to form the uterine folds with an endometrial cavity and the fusion of the both uterine folds together to form the unicavital (normal) uterus. In the uterine folds there are closer cell-to-cell communications, polypotential germ cells differentiate and grow into myometrium and endometrial layers.Some of the polypotential germ cells fail to reach the ridges and stay in the peritoneal cavity, where they may be transforming into external endometrial heterotopies.The main insight in the etiology of endometriosis is polypotential germ cells origin, which may explain its potency, pathogenesis and expansion.

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子宫内膜异位症起源于原始生殖细胞。
子宫内膜异位症的定义是存在子宫内膜异位。为了了解不同的临床证据,人们提出了多种假说来解释子宫内膜异位症的病因。子宫内膜异位症的病因尚不清楚。了解子宫内膜异位(子宫内膜异位症)病因的主要问题是确定异位(通常引用)子宫内膜的起源。根据新的理论,原始生殖细胞从下胚层(靠近尿囊的卵黄囊)迁移到性腺脊。由原始生殖细胞组成的性腺脊依次发育为异位子宫内膜、卵巢、卵巢韧带和子宫圆韧带。子宫器官发生有两个主要过程:性腺脊与肾系管相交形成子宫褶皱和子宫内膜腔,两个子宫褶皱融合在一起形成单腔(正常)子宫。在子宫褶皱中,细胞间的交流更紧密,多能生殖细胞分化并长成肌层和子宫内膜层。一些多能生殖细胞不能到达嵴并停留在腹腔内,在那里它们可能转化为外子宫内膜异位。子宫内膜异位症病因学的主要观点是多潜能生殖细胞的起源,这可能解释其效力、发病机制和扩张。
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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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