Chao Liang, Hui Pan, Haizhou Li, Yang Zhao, Yang Feng
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引用次数: 0
Abstract
Purpose: The purpose of this study was to evaluate the anticancer activity of 10 selected traditional Chinese medicinal plants on 4 cancer cell lines, namely MCF-7 (breast carcinoma), BALL-1 (acute lymphoblastic leukemia), Huh-7 (hepatocellular carcinoma), HeLa (cervical carcinoma) and their cytotoxicity on a normal cell line, namely MCF-10A (non-tumorigenic mammary epithelial line), about which there were few reports previously.
Methods: Six phytochemical extracts, namely petroleum ether extract (PEE), chloroform extract (CE), ethyl acetate extract (EAE), n-butanol extract (BE), the remainder after extraction (RE) and water extract (WE) from each plant were prepared. These 60 extracts were screened for their cytotoxicity on the aforementioned cell lines using MTT assay.
Results: All plant species showed certain anticancer activity against at least one of the 4 cancer cell lines and obvious selective cytotoxicities were observed. Compared with Huh-7 and HeLa cells, MCF-7 and BALL-1 cells were more sensitive to the treatments of the phytochemical extracts. The PEE, CE and EAE of Brassica campestris, the PE and CE of Hibiscus syriacus, as well as the BE of Pittosporum tobira exhibited strong anticancer activity but weak cytotoxicity on the normal cell line.
Conclusion: Our results provided new evidence for anticancer activities of these plants which could be useful for developing new anticancer therapies.
期刊介绍：
JBUON aims at the rapid diffusion of scientific knowledge in Oncology.
Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board.
With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world.
With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers.
JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.
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