Yishuo Zhu, Xuan Wang, Yujie Cui, Jin Bai, Junnian Zheng, Yuechao Fan
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引用次数: 0
Abstract
Purpose: The aim was to demonstrate the progression of glioma influenced by Vitamin C (VC) and the potential molecular mechanism.
Methods: Proliferative and migratory rates of U87 and U251 cells induced with 0, 50 and 100 µM VC were examined by CCK-8 and Transwell assay, respectively. Clinical significance of SYNPO2 in glioma patients was analyzed. Relative level of SYNPO2 in VC-induced glioma cells was detected. By intervening SYNPO2, the involvement of SYNPO2 in the anti-cancer role of VC in inhibiting glioma cell phenotypes was finally confirmed.
Results: VC induction dose-dependently attenuated proliferative and migratory potentials of glioma cells. A low level of SYNPO2 indicated poor prognosis of glioma. Protein and mRNA levels of SYNPO2 were upregulated in glioma cells induced with VC. The inhibitory effects of VC on proliferative and migratory potentials of glioma cells were partially reversed by knockdown of SYNPO2.
Conclusions: VC blocks glioma cells to proliferate and migrate by upregulating SYNPO2.
期刊介绍：
JBUON aims at the rapid diffusion of scientific knowledge in Oncology.
Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board.
With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world.
With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers.
JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.
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