Monte Carlo Simulation for Polychromatic X-Ray Fluorescence Computed Tomography with Sheet-Beam Geometry.

IF 3.3 Q2 ENGINEERING, BIOMEDICAL International Journal of Biomedical Imaging Pub Date : 2017-01-01 Epub Date: 2017-05-08 DOI:10.1155/2017/7916260
Shanghai Jiang, Peng He, Luzhen Deng, Mianyi Chen, Biao Wei
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引用次数: 8

Abstract

X-ray fluorescence computed tomography (XFCT) based on sheet beam can save a huge amount of time to obtain a whole set of projections using synchrotron. However, it is clearly unpractical for most biomedical research laboratories. In this paper, polychromatic X-ray fluorescence computed tomography with sheet-beam geometry is tested by Monte Carlo simulation. First, two phantoms (A and B) filled with PMMA are used to simulate imaging process through GEANT 4. Phantom A contains several GNP-loaded regions with the same size (10 mm) in height and diameter but different Au weight concentration ranging from 0.3% to 1.8%. Phantom B contains twelve GNP-loaded regions with the same Au weight concentration (1.6%) but different diameter ranging from 1 mm to 9 mm. Second, discretized presentation of imaging model is established to reconstruct more accurate XFCT images. Third, XFCT images of phantoms A and B are reconstructed by filter back-projection (FBP) and maximum likelihood expectation maximization (MLEM) with and without correction, respectively. Contrast-to-noise ratio (CNR) is calculated to evaluate all the reconstructed images. Our results show that it is feasible for sheet-beam XFCT system based on polychromatic X-ray source and the discretized imaging model can be used to reconstruct more accurate images.

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基于板束几何的多色x射线荧光计算机断层扫描蒙特卡罗模拟。
基于片束的x射线荧光计算机断层扫描(XFCT)可以节省大量的时间,通过同步加速器获得一整套投影。然而,对于大多数生物医学研究实验室来说,这显然是不切实际的。本文通过蒙特卡罗模拟对具有板束几何结构的多色x射线荧光计算机断层扫描进行了测试。首先,利用两个充满PMMA的幻影(A和B),通过geant4模拟成像过程。幻影A包含几个gnp负载区域,其高度和直径大小相同(10毫米),但Au重量浓度不同,范围从0.3%到1.8%。幻影B包含12个负载gnp的区域,它们具有相同的Au重量浓度(1.6%),但直径从1毫米到9毫米不等。其次,建立成像模型的离散化表示,以重建更精确的XFCT图像;第三,分别采用滤波反投影法(FBP)和最大似然期望最大化法(MLEM)对幻影A和B的XFCT图像进行校正和不校正重建。计算噪声比(CNR)对所有重建图像进行评价。结果表明,该方法在基于多色x射线源的板束XFCT系统中是可行的,离散化成像模型可用于重建更精确的图像。
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来源期刊
CiteScore
12.00
自引率
0.00%
发文量
11
审稿时长
20 weeks
期刊介绍: The International Journal of Biomedical Imaging is managed by a board of editors comprising internationally renowned active researchers. The journal is freely accessible online and also offered for purchase in print format. It employs a web-based review system to ensure swift turnaround times while maintaining high standards. In addition to regular issues, special issues are organized by guest editors. The subject areas covered include (but are not limited to): Digital radiography and tomosynthesis X-ray computed tomography (CT) Magnetic resonance imaging (MRI) Single photon emission computed tomography (SPECT) Positron emission tomography (PET) Ultrasound imaging Diffuse optical tomography, coherence, fluorescence, bioluminescence tomography, impedance tomography Neutron imaging for biomedical applications Magnetic and optical spectroscopy, and optical biopsy Optical, electron, scanning tunneling/atomic force microscopy Small animal imaging Functional, cellular, and molecular imaging Imaging assays for screening and molecular analysis Microarray image analysis and bioinformatics Emerging biomedical imaging techniques Imaging modality fusion Biomedical imaging instrumentation Biomedical image processing, pattern recognition, and analysis Biomedical image visualization, compression, transmission, and storage Imaging and modeling related to systems biology and systems biomedicine Applied mathematics, applied physics, and chemistry related to biomedical imaging Grid-enabling technology for biomedical imaging and informatics
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