Lauren L Siewertsz van Reesema, Michael P Lee, Vasilena Zheleva, Janet S Winston, Caroline F O'Connor, Roger R Perry, Richard A Hoefer, Amy H Tang
{"title":"RAS pathway biomarkers for breast cancer prognosis.","authors":"Lauren L Siewertsz van Reesema, Michael P Lee, Vasilena Zheleva, Janet S Winston, Caroline F O'Connor, Roger R Perry, Richard A Hoefer, Amy H Tang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Metastatic breast cancer is a highly heterogeneous, rapidly evolving and devastating disease that challenges our ability to find curative therapies. RAS pathway activation is an understudied research area in breast cancer. EGFR/RAS pathway activation is prevalent in breast cancer with poor prognosis. The prognostic RAS pathway biomarkers can be used to identify resistant tumour clones, stratify patients and guide therapies.</p>","PeriodicalId":91230,"journal":{"name":"Clinical laboratory international","volume":"40 ","pages":"18-23"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455995/pdf/nihms866728.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory international","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Metastatic breast cancer is a highly heterogeneous, rapidly evolving and devastating disease that challenges our ability to find curative therapies. RAS pathway activation is an understudied research area in breast cancer. EGFR/RAS pathway activation is prevalent in breast cancer with poor prognosis. The prognostic RAS pathway biomarkers can be used to identify resistant tumour clones, stratify patients and guide therapies.
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