{"title":"Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study.","authors":"Sheida Khosravani, Farhad Handjani, Reyhaneh Alimohammadi, Nasrin Saki","doi":"10.1155/2017/6053267","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND).</p><p><strong>Objective: </strong>The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients.</p><p><strong>Methods: </strong>In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19.</p><p><strong>Results: </strong>Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (<i>P</i> = 0.022). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (<i>P</i> = 0.008). In this study, the incidences of Parkinson's disease (<i>P</i> = 0.830), epilepsy (<i>P</i> = 0.067), and multiple sclerosis (<i>P</i> = 0.326) were not statistically significant between the two groups.</p><p><strong>Conclusion: </strong>The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.</p>","PeriodicalId":14433,"journal":{"name":"International Scholarly Research Notices","volume":"2017 ","pages":"6053267"},"PeriodicalIF":0.0000,"publicationDate":"2017-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463116/pdf/","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Scholarly Research Notices","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2017/6053267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND).
Objective: The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients.
Methods: In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19.
Results: Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (P = 0.022). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (P = 0.008). In this study, the incidences of Parkinson's disease (P = 0.830), epilepsy (P = 0.067), and multiple sclerosis (P = 0.326) were not statistically significant between the two groups.
Conclusion: The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.
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