{"title":"[Fillagrin - Multifunctional Protein].","authors":"","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Effective physical, chemical, biochemical and immune function of the skin requires a corresponding structure of the\nepidermis. Filaggrin, one of epidermal proteins, is essential for the formation of corneocytes and intracellular metabolites,\nwhich in turn contribute to maintaining the stratum corneum humidity and acidic pH of the skin surface. However, a number\nof profilaggrin gene mutations have been described, as well as different inflammatory conditions and different external\nfactors that all resulted in filaggrin deficiency. Filaggrin deficiency is recorded in different skin diseases and discoveries\nrelated to metabolic processing of filaggrin point to new goals in therapeutic strategies. In this preview, the main properties\nof the formation and metabolism of filaggrin are described, as well as clinical implications of filaggrin deficiency in the\netiopathogenesis of some skin diseases.</p>","PeriodicalId":35756,"journal":{"name":"Acta Medica Croatica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Croatica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Effective physical, chemical, biochemical and immune function of the skin requires a corresponding structure of the
epidermis. Filaggrin, one of epidermal proteins, is essential for the formation of corneocytes and intracellular metabolites,
which in turn contribute to maintaining the stratum corneum humidity and acidic pH of the skin surface. However, a number
of profilaggrin gene mutations have been described, as well as different inflammatory conditions and different external
factors that all resulted in filaggrin deficiency. Filaggrin deficiency is recorded in different skin diseases and discoveries
related to metabolic processing of filaggrin point to new goals in therapeutic strategies. In this preview, the main properties
of the formation and metabolism of filaggrin are described, as well as clinical implications of filaggrin deficiency in the
etiopathogenesis of some skin diseases.
期刊介绍:
ACTA MEDICA CROATICA publishes original contributions to medical sciences, that have not been previously published. All manuscripts should be written in English.