Gold Nanoparticles for Radiation Enhancement in Vivo.

Jacobs journal of radiation oncology Pub Date : 2016-04-01 Epub Date: 2016-04-27
Samana Shrestha, Leon N Cooper, Oleg A Andreev, Yana K Reshetnyak, Michael P Antosh
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Abstract

Enhancing the effect of radiation on tumors would be a significant improvement in radiation therapy. With radiation enhancement, less radiation could be used to achieve the same goals, lessening damage to healthy tissue and lessening side effects. Gold nanoparticles are a promising method for achieving this enhancement, particularly when the gold nanoparticles are targeted to cancer. This literature review discusses the properties of gold nanoparticles as well as existing in vivo radiation enhancement results using both targeted and non-targeted gold nanoparticles.

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金纳米颗粒在体内增强辐射。
增强放射治疗对肿瘤的作用将是放射治疗的重大改进。通过增强辐射,可以使用更少的辐射来达到同样的目的,减少对健康组织的损害,减少副作用。金纳米颗粒是实现这种增强的一种很有前途的方法,特别是当金纳米颗粒针对癌症时。本文综述了金纳米颗粒的性质以及现有的靶向和非靶向金纳米颗粒在体内的辐射增强效果。
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Gold Nanoparticles for Radiation Enhancement in Vivo. Interobserver and intermodality variability in GTV delineation on simulation CT, FDG-PET, and MR Images of Head and Neck Cancer. A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells.
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