The correlation between cognitive impairment and ambulatory blood pressure in patients with cerebral small vessel disease.

IF 3.3 4区医学 Q1 Medicine European review for medical and pharmacological sciences Pub Date : 2017-07-01

X-F Li, L-M Cui, D-K Sun, H-T Wang, W-G Liu

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Abstract

Objective: The present study was aimed to analyze the correlation between cognitive impairment and ambulatory blood pressure in patients with cerebral small vessel disease (CSVD).

Patients and methods: 108 patients with CSVD received in our hospital were selected. Assessment of cognitive impairment was by the Montreal Cognitive Assessment (MoCA). 39 cases were established as the impairment group and 69 cases were established as the normal group. 24 h ambulatory blood pressure was monitored, and changes in ambulatory blood pressure parameters between the two groups were compared. Also, the correlation between blood pressure parameters and MoCA score were analyzed.

Results: Comparisons of ambulatory systolic blood pressure, ambulatory pulse pressure and the ratios of night blood pressure reduction of patients in both groups showed statistical differences (p < 0.05), while the changes in diastolic blood pressure showed no statistical differences (p > 0.05). The comparison of the blood pressure curves in both groups showed statistical differences (p < 0.05). The ambulatory systolic blood pressure, ambulatory pulse pressure and the ratio of night blood pressure reduction of patients with CSVD showed prominently negative correlations with MoCA score (p < 0.05).

Conclusions: Cognitive impairment and the ambulatory blood pressure of patients with CSVD are intimately correlated. The rise of ambulatory systolic blood pressure, pulse pressure, and the decline of blood pressure may represent risk factors for cognitive impairment in patients with CSVD. Improving blood pressure management will reduce the incidence of cognitive impairment caused by CSVD.

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脑血管病患者认知功能障碍与动态血压的关系。

目的:分析脑小血管疾病(CSVD)患者认知功能障碍与动态血压的相关性。患者和方法:选择我院收治的CSVD患者108例。认知障碍评估采用蒙特利尔认知评估(MoCA)。损伤组39例，正常组69例。监测24 h动态血压，比较两组动态血压参数的变化。并分析血压参数与MoCA评分的相关性。结果:两组患者动态收缩压、动态脉压及夜间降压比例比较，差异有统计学意义(p < 0.05)，舒张压变化无统计学意义(p > 0.05)。两组血压曲线比较，差异有统计学意义(p < 0.05)。CSVD患者的动态收缩压、动态脉压、夜间血压降低率与MoCA评分呈显著负相关(p < 0.05)。结论:认知功能障碍与CSVD患者的动态血压密切相关。动态收缩压、脉压升高和血压下降可能是心血管疾病患者认知功能障碍的危险因素。改善血压管理将减少心血管疾病引起的认知障碍的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)