ADAM23 promotes neuronal differentiation of human neural progenitor cells.

IF 10.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cellular & Molecular Biology Letters Pub Date : 2017-08-18 eCollection Date: 2017-01-01 DOI:10.1186/s11658-017-0045-1

Annett Markus-Koch, Oliver Schmitt, Susanne Seemann, Jan Lukas, Dirk Koczan, Mathias Ernst, Georg Fuellen, Andreas Wree, Arndt Rolfs, Jiankai Luo

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引用次数: 9

Abstract

Background: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation.

Results: In this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor cells (hNPCs). Upregulation of ADAM23 in hNPCs was found to increase the number of neurons and the length of neurite, while its downregulation decreases them and triggers cell apoptosis. RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- or downregulation of ADAM23.

Conclusions: Our results suggest that ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during hNPC differentiation.

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ADAM23促进人神经祖细胞的神经元分化。

背景:ADAM23在胚胎中枢神经系统中广泛表达，在组织形成中起重要作用。结果:在本研究中，我们发现ADAM23在人神经祖细胞(hNPCs)分化过程中参与细胞存活和神经元分化。研究发现，ADAM23在hNPCs中上调可增加神经元数量和神经突长度，下调ADAM23可减少神经元数量和神经突长度并引发细胞凋亡。RNA微阵列分析揭示了ADAM23上调或下调可能参与多种细胞过程的基因和途径的机制。结论:我们的研究结果表明，ADAM23通过触发hNPC分化过程中的特定信号通路来调节神经元分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular & Molecular Biology Letters 生物-生化与分子生物学

CiteScore

11.60

自引率

13.30%

发文量

101

审稿时长

3 months

期刊介绍： Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.