Analysis of Genetic Variation of Two NADC30-like Strains of Porcine Reproductive and Respiratory Syndrome Virus in China.

The Open Virology Journal Pub Date : 2017-06-30 eCollection Date: 2017-01-01 DOI:10.2174/1874357901711010090

Zhi Zhou, Jiajun Wu, Shuo Zhang, Bo Hou, Tao Han, Jing Wang, Qi Xu, Dongyue Wang, Yinyi Liu, Shengpeng Xin, Xinyan Zhai

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引用次数: 1

Abstract

Background: NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012.

Objective and method: To explore the possible genetic diversity of these strains, we sequenced and analyzed the complete genomes of two NADC30-like strains. These isolates shared 95.4% homology with NADC30.

Result: The two strains displayed a discontinuous deletion of 131 amino acids in NSP2, mutations of amino acids in GP3 and GP5, and a 3-nucleotide deletion in the 3' untranslated region. Phylogenetic analysis showed that the two isolates formed a new branch and clustered in a subgroup with NADC30 isolates from North America.

Conclusion: We conclude that the above two NADC30-like strains may have been introduced from North America to China, where they acquired new genetic diversity.

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中国猪繁殖与呼吸综合征病毒两个nadc30样毒株的遗传变异分析

背景:猪繁殖与呼吸综合征病毒nadc30样毒株于2012年首次在中国猪群中出现。目的和方法:对2株nadc30样菌株进行全基因组测序和分析，探讨其可能的遗传多样性。这些分离株与NADC30具有95.4%的同源性。结果:两株菌株在NSP2中不连续缺失131个氨基酸，GP3和GP5中氨基酸突变，3'非翻译区缺失3个核苷酸。系统发育分析表明，这两个分离株形成了一个新的分支，并与来自北美的NADC30分离株聚在一个亚群中。结论:上述两个nadc30样菌株可能是从北美传入中国的，并在中国获得了新的遗传多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Open Virology Journal

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