Tomoya Nakamura, Naoki Yoshida, Mitsue Yasoshima, Yoshihiko Kojima
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引用次数: 5
Abstract
In this study, we investigated how tannic acid (TA) protects the skin from inflammation caused by external irritation. The effects of TA were evaluated using a mouse 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin inflammation model and a reconstructed human epidermal model. We then used Lucifer Yellow for visual confirmation of TA's suppression effect at the stratum corneum (SC) surface. TA treatment of the skin prevented Lucifer Yellow from permeating the skin. This result suggests that TA acts as a barrier against external stimulants such as TPA and artificial sweat on the SC surface.
在这项研究中，我们研究了单宁酸(TA)如何保护皮肤免受外部刺激引起的炎症。采用小鼠12- o -十四烷酚13-乙酸酯(TPA)诱导的皮肤炎症模型和重建的人表皮模型来评价TA的作用。然后，我们使用路西法黄来视觉确认TA在角质层(SC)表面的抑制效果。TA对皮肤的处理阻止了路西法黄渗透皮肤。这一结果表明，TA可以作为一种屏障，抵御外部刺激物，如TPA和SC表面的人工汗液。
期刊介绍：
Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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