Anti-anxiety and Anti-depressant Like Effects of Murraya koenigii in Experimental Models of Anxiety and Depression.

Snigdha Sharma, Shailendra Handu, Ashok Kumar Dubey, Prashant Sharma, Pramod Mediratta, Qazi Mushtaq Ahmed
{"title":"Anti-anxiety and Anti-depressant Like Effects of <i>Murraya koenigii</i> in Experimental Models of Anxiety and Depression.","authors":"Snigdha Sharma,&nbsp;Shailendra Handu,&nbsp;Ashok Kumar Dubey,&nbsp;Prashant Sharma,&nbsp;Pramod Mediratta,&nbsp;Qazi Mushtaq Ahmed","doi":"10.4103/asl.ASL_75_17","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Presence of free radical scavenging activity in <i>Murraya</i><i>koenigii</i>, commonly known as Curry leaves, has been shown in previous studies. Oxidative stress plays an important role in the development of various neurobehavioral disorders including anxiety and depression.</p><p><strong>Aim: </strong>The present study aimed to evaluate the effects of <i>Murraya koenigii</i> in animal models of depression and anxiety.</p><p><strong>Materials and methods: </strong>The effect of incremental doses of <i>Murraya koenigii</i> aqueous leaf extract was evaluated on spontaneous motor activity (SMA), open arm incursions in elevated plus maze, and despair behaviour in forced swim (FST) and tail suspension (TST) tests as compared to control groups in Swiss albino mice.</p><p><strong>Results: </strong><i>Murraya koenigii</i> 300 mg/kg, p.o. (MK300) and 400 mg/kg, p.o. (MK400) reduced the SMA count from 754 ± 64.9 to 540 ± 29 and 295 ± 34 respectively, which was statistically significant. MK300 and MK400 reduced significantly the open arm count from 29 ± 8.6 to 16 ± 7 and 10 ± 3.9, respectively. On FST, MK400 reduced the duration of immobility from 145.5 ± 29 to 91 ± 17.3, which was statistically significant. On TST, MK produced a dose-dependent decrease in the duration of immobility; however, it was statistically significant only with MK400.</p><p><strong>Conclusion: </strong><i>Murraya koenigii</i> aqueous leaf extract reduced the despair behavior in experimental animal models, suggesting an anti-depressant like activity. <i>Murraya koenigii</i> extract also reduced spontaneous locomotor activity in a dose-dependent manner suggesting a sedative and/or anxiolytic effect though there wasn't any anxiolytic effect in the elevated plus maze test.</p>","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 4","pages":"215-219"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726189/pdf/","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ancient Science of Life","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/asl.ASL_75_17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

Background: Presence of free radical scavenging activity in Murrayakoenigii, commonly known as Curry leaves, has been shown in previous studies. Oxidative stress plays an important role in the development of various neurobehavioral disorders including anxiety and depression.

Aim: The present study aimed to evaluate the effects of Murraya koenigii in animal models of depression and anxiety.

Materials and methods: The effect of incremental doses of Murraya koenigii aqueous leaf extract was evaluated on spontaneous motor activity (SMA), open arm incursions in elevated plus maze, and despair behaviour in forced swim (FST) and tail suspension (TST) tests as compared to control groups in Swiss albino mice.

Results: Murraya koenigii 300 mg/kg, p.o. (MK300) and 400 mg/kg, p.o. (MK400) reduced the SMA count from 754 ± 64.9 to 540 ± 29 and 295 ± 34 respectively, which was statistically significant. MK300 and MK400 reduced significantly the open arm count from 29 ± 8.6 to 16 ± 7 and 10 ± 3.9, respectively. On FST, MK400 reduced the duration of immobility from 145.5 ± 29 to 91 ± 17.3, which was statistically significant. On TST, MK produced a dose-dependent decrease in the duration of immobility; however, it was statistically significant only with MK400.

Conclusion: Murraya koenigii aqueous leaf extract reduced the despair behavior in experimental animal models, suggesting an anti-depressant like activity. Murraya koenigii extract also reduced spontaneous locomotor activity in a dose-dependent manner suggesting a sedative and/or anxiolytic effect though there wasn't any anxiolytic effect in the elevated plus maze test.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在焦虑和抑郁实验模型中的抗焦虑和抗抑郁样作用。
背景:先前的研究表明,咖喱叶具有清除自由基的活性。氧化应激在包括焦虑和抑郁在内的各种神经行为障碍的发展中起着重要作用。目的:本研究旨在评价柯氏菌对抑郁和焦虑动物模型的影响。材料和方法:与对照组相比,我们评估了增加剂量的木藤叶水提取物对瑞士白化小鼠自发性运动活动(SMA)、升高+迷宫中的张开手臂侵入以及强迫游泳(FST)和悬尾(TST)测试中的绝望行为的影响。结果:300 mg/kg, p.o. (MK300)和400 mg/kg, p.o. (MK400)使SMA计数分别从754±64.9减少到540±29和295±34,差异有统计学意义。MK300和MK400分别将张开臂数从29±8.6减少到16±7和10±3.9。在FST上,MK400将静止时间从145.5±29缩短至91±17.3,具有统计学意义。在TST上,MK使静止时间呈剂量依赖性减少;然而,只有MK400才有统计学意义。结论:龙涎香叶水提物降低了实验动物的绝望行为,具有抗抑郁作用。Murraya koenigii提取物也以剂量依赖的方式降低自发运动活动,提示镇静和/或抗焦虑作用,尽管在升高+迷宫试验中没有任何抗焦虑作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
审稿时长
39 weeks
期刊最新文献
Vaidyaka Paribhasha Pradipa: A treatise on technical terminologies of Bhaishajya Kalpana (Ayurvedic Pharmaceutics) Herbal emulgel containing Azadirachta indica (Neem) and Nigella Sativa L. (Black Cumin) oils in wound management: Preclinical investigations Quantitative estimation of secondary metabolites of shadanga paniya classical ayurvedic formulation and constituent herbs Editorial note – Resurgent Ayurveda and resurging research on Ayurveda A proposal for “Ayurveda and informatics” as a modular course in BTech engineering program
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1