[Peculiarities of Allergy Diagnosis in Children].

L S Namazova-Barahona, M A Snovskaya, I L Mitushin, O V Kozhevnikova, A S Batyrova
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引用次数: 8

Abstract

Allergic disease is a serious problem in practical healthcare. Over the last 40 years there has been exponential growth in the prevalence. According to the world health organization information, allergic diseases are at the 2nd place in prevalence the children, behind the viral infections. Their frequency and severity are increasing. In this regard, the relevance of timely and skilled diagnostic allergopathology is most important. In this study the current state of the question of allergy diagnostics is considered, the international experience is summarized and the approach to the allergy diagnosis based on use of step-by-step identification of a causal and significant factor of allergic reactions is offered. On the basis of the analysis of relevance and the importance for patients of one or the other allergens (taking into account a source of allergens and age of patients) use of a step-by-step allergy diagnostics algorithm is offered. The first step is definition of clinical implications of an allergy. It means direct contact of the phisition with the patient, clarification of its complaints, clinical symptoms, medical history disease. The second step is the confirmation of IgE-dependent mechanism. It involves the using of screening tests that are selected depending on the clinical symptoms and seasonality manifestations (the screening module). The third step is to identify the source of the allergens that are most meaningful for the patient with using test panels (modules). The panels include the most common and clinically relevant triggers of allergic reactions. The fourth step is the search for an individual significant allergens, which were not included in the diagnostic modules. On the fifth step, we plan to conduct component-divided diagnostics and detect the antibodies to unique components of significant allergens. The developed diagnostics algorithm, corresponds to needs of both the adult, and children’s population and provides the personalized approach to the patients.

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[儿童过敏诊断的特点]。
变态反应性疾病是实际医疗保健中的一个严重问题。在过去的40年里,发病率呈指数级增长。根据世界卫生组织的资料,过敏性疾病在儿童患病率中排名第二,仅次于病毒感染。它们发生的频率和严重程度都在增加。在这方面,及时和熟练的诊断过敏症病理是最重要的。在本研究中,考虑了过敏诊断问题的现状,总结了国际经验,并提供了基于逐步识别过敏反应的因果和重要因素的过敏诊断方法。在分析一种或另一种过敏原对患者的相关性和重要性的基础上(考虑到过敏原的来源和患者的年龄),提供了一种逐步过敏诊断算法的使用。第一步是定义过敏的临床意义。指与病人直接接触,澄清病人的主诉、临床症状、病史和疾病。第二步是ige依赖机制的确认。它涉及使用根据临床症状和季节性表现选择的筛选试验(筛选模块)。第三步是通过使用测试面板(模块)来确定对患者最有意义的过敏原来源。这些小组包括最常见和临床相关的过敏反应触发因素。第四步是寻找个体重要的过敏原,这些过敏原未包括在诊断模块中。第五步,我们计划进行成分划分诊断,检测针对重要过敏原的独特成分的抗体。开发的诊断算法,符合成人和儿童人群的需求,并为患者提供个性化的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
31
期刊最新文献
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