Huba Kalász, Julianna Thuróczy, Gellért Karvaly, Lajos Balogh, István Gyertyán, Edit Tóth-Molnár, Ernest Adeghate, Kornélia Tekes
{"title":"Effects on Sperms' Quality of Selegiline in Aged Rats.","authors":"Huba Kalász, Julianna Thuróczy, Gellért Karvaly, Lajos Balogh, István Gyertyán, Edit Tóth-Molnár, Ernest Adeghate, Kornélia Tekes","doi":"10.2174/1874104501711010138","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.</p><p><strong>Objective: </strong>Scouting special and beneficial side effects of selegiline treatment.</p><p><strong>Method: </strong>Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.</p><p><strong>Results: </strong>Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.</p><p><strong>Conclusion: </strong>Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.</p>","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"11 ","pages":"138-145"},"PeriodicalIF":0.0000,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748828/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicinal Chemistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874104501711010138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.
Objective: Scouting special and beneficial side effects of selegiline treatment.
Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.
Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.
Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.