Pub Date : 2020-12-18DOI: 10.2174/1874842202007010037
M. K. Ahmad, Mais A. Mohammed, M. Barbooti
Many methods have been suggested for the removal of heavy metals from water to protect human health and the environment. Methods like precipitation and adsorption were proposed for this purpose. Electrocoagulation involves the generation of coagulant by the action of electricity on two metal electrodes (iron or aluminium) to aid the process of water decontamination. Electrodeposition cell was made with iron electrodes and application of voltage from the power supply (5-25 V) dipped in the working solution (Cu and Zn) at various concentrations (10-50 mg.mL-1) for 30-150 min. Samples were drawn and analysed by atomic absorption spectrophotometry. The work indicated efficient removal of the metal ions. The dependence of removal efficiency on the three parameters was studied. The behaviour of the two metal ions was not identical. At low initial concentration, the electrolysis voltage was very important in the removal of Zn and Cu ions. Electrolysis time is essential in the removal process and shows a polynomial dependence of removal efficiency on time. Electrolysis time of 150 min resulted in almost complete removal (94-97%) regardless of the initial concentration. Both co-precipitation and adsorption mechanisms may be involved. The removal efficiency was directly dependent on the initial metal ion concentration and electrolysis time. The process gave removal efficiency for copper that is higher than that of the zinc.
{"title":"Electrocoagulation for the Removal of Copper and Zinc Ions from Water Using Iron Electrodes","authors":"M. K. Ahmad, Mais A. Mohammed, M. Barbooti","doi":"10.2174/1874842202007010037","DOIUrl":"https://doi.org/10.2174/1874842202007010037","url":null,"abstract":"\u0000 \u0000 Many methods have been suggested for the removal of heavy metals from water to protect human health and the environment. Methods like precipitation and adsorption were proposed for this purpose.\u0000 \u0000 \u0000 \u0000 Electrocoagulation involves the generation of coagulant by the action of electricity on two metal electrodes (iron or aluminium) to aid the process of water decontamination.\u0000 \u0000 \u0000 \u0000 Electrodeposition cell was made with iron electrodes and application of voltage from the power supply (5-25 V) dipped in the working solution (Cu and Zn) at various concentrations (10-50 mg.mL-1) for 30-150 min. Samples were drawn and analysed by atomic absorption spectrophotometry.\u0000 \u0000 \u0000 \u0000 The work indicated efficient removal of the metal ions. The dependence of removal efficiency on the three parameters was studied. The behaviour of the two metal ions was not identical. At low initial concentration, the electrolysis voltage was very important in the removal of Zn and Cu ions. Electrolysis time is essential in the removal process and shows a polynomial dependence of removal efficiency on time. Electrolysis time of 150 min resulted in almost complete removal (94-97%) regardless of the initial concentration. Both co-precipitation and adsorption mechanisms may be involved.\u0000 \u0000 \u0000 \u0000 The removal efficiency was directly dependent on the initial metal ion concentration and electrolysis time. The process gave removal efficiency for copper that is higher than that of the zinc.\u0000","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73988297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-31DOI: 10.2174/1874842201906010034
Andrea R Costantino, J. Neudörfl, Romina A. Ocampo, Laura A. Svetaz, S. Zacchino, L. Koll, Sandra D. Mandolesi
Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities. Hence, it is important to study the synthesis of new organotin compounds with low toxicity that may be of pharmacological interest. This study focuses on the synthesis of new bis-stannylated derivatives with C2 symmetry that could be tested as antifungal agents against two clinical important fungal species, Cryptococcus neoformans and Candida albicans. The radical addition of triorganotin hydrides (R3SnH) and diorganotin chlorohydrides (R2ClSnH) to bis-α,β-unsaturated diesters derived from (S)-BINOL led to the corresponding new bis-stannylated derivatives with C2 symmetry. Nine pure organotin compounds were synthesized with defined stereochemistry. Four of them were enantiomerically pure and four were diastereoisomeric mixtures. All new organotin compounds were fully characterized, those with phenyl ligands bonded to tin were the most active compounds against both the strains (Cryptococcus neoformans and Candida albicans), with activity parameters of IC50 close to those of the reference drug (amphotericin B). Nine pure organotin compounds with C2 symmetry were synthesized with defined stereochemistry and their antifungal properties were tested against two clinical important fungi with IC values close to those of the reference drug. The structure-containing preferably two or three phenyl groups joined to the tin atom were highly active against both the strains compared with those possessing tri-n-butyl groups.
{"title":"Synthesis, Characterization and Antifungal Assessment of Optically Active Bis-organotin Compounds Derived from (S)-BINOL Diesters","authors":"Andrea R Costantino, J. Neudörfl, Romina A. Ocampo, Laura A. Svetaz, S. Zacchino, L. Koll, Sandra D. Mandolesi","doi":"10.2174/1874842201906010034","DOIUrl":"https://doi.org/10.2174/1874842201906010034","url":null,"abstract":"\u0000 \u0000 Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities. Hence, it is important to study the synthesis of new organotin compounds with low toxicity that may be of pharmacological interest.\u0000 \u0000 \u0000 \u0000 This study focuses on the synthesis of new bis-stannylated derivatives with C2 symmetry that could be tested as antifungal agents against two clinical important fungal species, Cryptococcus neoformans and Candida albicans.\u0000 \u0000 \u0000 \u0000 The radical addition of triorganotin hydrides (R3SnH) and diorganotin chlorohydrides (R2ClSnH) to bis-α,β-unsaturated diesters derived from (S)-BINOL led to the corresponding new bis-stannylated derivatives with C2 symmetry. Nine pure organotin compounds were synthesized with defined stereochemistry. Four of them were enantiomerically pure and four were diastereoisomeric mixtures.\u0000 \u0000 \u0000 \u0000 All new organotin compounds were fully characterized, those with phenyl ligands bonded to tin were the most active compounds against both the strains (Cryptococcus neoformans and Candida albicans), with activity parameters of IC50 close to those of the reference drug (amphotericin B).\u0000 \u0000 \u0000 \u0000 Nine pure organotin compounds with C2 symmetry were synthesized with defined stereochemistry and their antifungal properties were tested against two clinical important fungi with IC values close to those of the reference drug. The structure-containing preferably two or three phenyl groups joined to the tin atom were highly active against both the strains compared with those possessing tri-n-butyl groups.\u0000","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"228 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77331493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-21DOI: 10.2174/1874842201906010010
L. Zappe, C. Lochenie, Thomas Martin, Birgit Weber
The synthesis of four new iron(II) coordination polymers [Fe(L1a)(bpua)] (1), [Fe(L1b)(bpua)](0.5bpua) (2), [Fe(L2a)(bpua)] (3), [Fe(L1b)(bpua)](yEtOH) (5) and one trinuclear complex [{Fe(L1a)(bpua)(MeOH)}2-µ{Fe(L1a)}](xMeOH) (4) with Schiff base-like N2O2coordinating equatorial ligands (L1a, L1b and L2a) and 4,4’-bis(pyridyl)urea (bpua) as bridging axial ligand is described.Single crystal X-ray structure elucidation of the trinuclear module4and of the coordination polymer5reveals the presence of HS-LS-HS chains and all-HS infinite 1-D strands, respectively. As anticipated the presence of the bridging urea supports the supramolecular concatenation within an extended hydrogen-bonding network. Magnetic measurements reveal spin crossover behavior for four of the five complexes (1–4) that is strongly solvent dependent.Interestingly, in two cases, complete removal of the solvent from the crystal packing leads to wider thermal hysteresis loops.
{"title":"Iron(II) Spin Crossover Polymers of Planar N2O2 Schiff Base Templates and 4,4’-bis(pyridyl)urea Bridges","authors":"L. Zappe, C. Lochenie, Thomas Martin, Birgit Weber","doi":"10.2174/1874842201906010010","DOIUrl":"https://doi.org/10.2174/1874842201906010010","url":null,"abstract":"The synthesis of four new iron(II) coordination polymers [Fe(L1a)(bpua)] (1), [Fe(L1b)(bpua)](0.5bpua) (2), [Fe(L2a)(bpua)] (3), [Fe(L1b)(bpua)](yEtOH) (5) and one trinuclear complex [{Fe(L1a)(bpua)(MeOH)}2-µ{Fe(L1a)}](xMeOH) (4) with Schiff base-like N2O2coordinating equatorial ligands (L1a, L1b and L2a) and 4,4’-bis(pyridyl)urea (bpua) as bridging axial ligand is described.Single crystal X-ray structure elucidation of the trinuclear module4and of the coordination polymer5reveals the presence of HS-LS-HS chains and all-HS infinite 1-D strands, respectively. As anticipated the presence of the bridging urea supports the supramolecular concatenation within an extended hydrogen-bonding network. Magnetic measurements reveal spin crossover behavior for four of the five complexes (1–4) that is strongly solvent dependent.Interestingly, in two cases, complete removal of the solvent from the crystal packing leads to wider thermal hysteresis loops.","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85084749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-28DOI: 10.2174/1874842201906010001
Ch. Himasekar, S. Mustafa, M. Babu
{"title":"Synthesis, Characterization of Mixed Cu(II) Pyridyl Tetrazoles and 1,10-Phenanthroline Complexes - DFT and Biological Activity","authors":"Ch. Himasekar, S. Mustafa, M. Babu","doi":"10.2174/1874842201906010001","DOIUrl":"https://doi.org/10.2174/1874842201906010001","url":null,"abstract":"","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84766635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.2174/1874842201805010182
N. Mathur, N. Jain, Arti Sharma
Copper is a very important metal because all forms of life require copper metals an essential micronutrient. Various biological processes, directly or indirectly are dependent on copper metal. Copper soaps are used as fungicides, bacteriosides, herbicides and insecticides. Copper complexes including heterocyclic compounds have attracted our attention in a magnificent way because of its utility in catalysis and biological functions. Their mechanism of synthesis, characterization and structural insight, are crucial for comprehending the criteria of the bonding and electronic interactions between the proximate metal center and chelating atoms. But still, there is a need to explore some of more biological properties for their wide applicability and significant usage in multiple fields because it is an untapped area with potentially tremendous value. Hence, in this paper, we report the synthesis and characterization of transition metal complex of N/S ligand by chromatographic, FT-IR, NMR, ESR, elemental analysis, conductometric and magnetic moment measurements. The synthesized metal complexes namely copper palmitate with 4-nitrophenylthiourea and copper palmitate with 4-methoxyphenylthiourea were successfully investigated for biological activities against fungi Candida albicans and Trichoderma harzinum. Based on the results, we pronounced biocidal activities of the novel complexes. It is concluded that the activity of nitro phenylthiourea complex has greater antifungal activity than methoxy phenylthiourea complex against these test fungi. We can conclude that the antifungal activity of these complexes varies according to the nature of the groups attached to the ligands.
{"title":"Synthesis, Characterization and Biological Analysis of Some Novel Complexes of Phenyl Thiourea Derivatives with Copper","authors":"N. Mathur, N. Jain, Arti Sharma","doi":"10.2174/1874842201805010182","DOIUrl":"https://doi.org/10.2174/1874842201805010182","url":null,"abstract":"\u0000 \u0000 Copper is a very important metal because all forms of life require copper metals an essential micronutrient. Various biological processes, directly or indirectly are dependent on copper metal.\u0000 \u0000 \u0000 \u0000 Copper soaps are used as fungicides, bacteriosides, herbicides and insecticides. Copper complexes including heterocyclic compounds have attracted our attention in a magnificent way because of its utility in catalysis and biological functions. Their mechanism of synthesis, characterization and structural insight, are crucial for comprehending the criteria of the bonding and electronic interactions between the proximate metal center and chelating atoms. But still, there is a need to explore some of more biological properties for their wide applicability and significant usage in multiple fields because it is an untapped area with potentially tremendous value. Hence, in this paper, we report the synthesis and characterization of transition metal complex of N/S ligand by chromatographic, FT-IR, NMR, ESR, elemental analysis, conductometric and magnetic moment measurements.\u0000 \u0000 \u0000 \u0000 The synthesized metal complexes namely copper palmitate with 4-nitrophenylthiourea and copper palmitate with 4-methoxyphenylthiourea were successfully investigated for biological activities against fungi Candida albicans and Trichoderma harzinum. Based on the results, we pronounced biocidal activities of the novel complexes.\u0000 \u0000 \u0000 \u0000 It is concluded that the activity of nitro phenylthiourea complex has greater antifungal activity than methoxy phenylthiourea complex against these test fungi. We can conclude that the antifungal activity of these complexes varies according to the nature of the groups attached to the ligands.\u0000","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73601223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.2174/1874842201805010172
B. Begum, N. Devanna, P. Chandra, R. Sultana
Received: July 23, 2018 Revised: September 7, 2018 Accepted: November 7, 2018 Abstract: Introduction: The increasing level of toxic metals in the environment is causing serious repercussions on the health of human beings. To mitigate the adverse effects of heavy metal concentration in the receiving waters, it is necessary to develop an affordable cost effective technology, which is effective to remove the heavy metals. The purpose of the present work is to investigate the removal of Nickel and Zinc ions from the water using known adsorbents. Chitin is a biopolymer used as as adsorbent to remove metal ions from the solution. Chitin is inexpensive adsorbent and is available abundantly.
{"title":"Removal of Zinc (II) and Ni (II) by using Bio-Polymer “Chitin”","authors":"B. Begum, N. Devanna, P. Chandra, R. Sultana","doi":"10.2174/1874842201805010172","DOIUrl":"https://doi.org/10.2174/1874842201805010172","url":null,"abstract":"Received: July 23, 2018 Revised: September 7, 2018 Accepted: November 7, 2018 Abstract: Introduction: The increasing level of toxic metals in the environment is causing serious repercussions on the health of human beings. To mitigate the adverse effects of heavy metal concentration in the receiving waters, it is necessary to develop an affordable cost effective technology, which is effective to remove the heavy metals. The purpose of the present work is to investigate the removal of Nickel and Zinc ions from the water using known adsorbents. Chitin is a biopolymer used as as adsorbent to remove metal ions from the solution. Chitin is inexpensive adsorbent and is available abundantly.","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88436332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-24DOI: 10.2174/1874842201805010158
G. Costa, C. R. C. Brito, A. Terezo, Adriana Cardoso, E. Y. Ionashiro, A. B. Siqueira
The interest in the antioxidant materials increased due to their free radical scavenging properties avoiding various pathologies. Tannic Acid (TA) is known to have high free radical scavenging activity, but its application is still limited. This paper had the objective of synthesis, characterization and evaluation of free radical scavenging activity of TA associated with Cu (II) and Zn (II) ions, in a buffered aqueous medium. Techniques of FTIR, simultaneous TG-DSC characterized the obtained compounds, and the evaluation of free radical scavenging activity was made using 2,2–diphenyl–1–picrylhydrazyl (DPPH) radical. The FTIR analysis of the compounds showed significant displacement of the main bands in the TA spectrum (νC=O, δO-H, σO-H), suggesting an association of metal ions with the oxygen of the hydroxyl group of TA. TG-DSC curves showed information about the thermal stability, stoichiometry, hydration water, and residues formation. The TA association with the metal ions Cu(II) and Zn(II) decreased the antioxidant activity of the molecule significantly, showing that these compounds could be potentially used as pro-oxidant agents.
{"title":"Preparation, Characterization and Antioxidant Evaluation of Cu(II) and Zn(II) Tannates","authors":"G. Costa, C. R. C. Brito, A. Terezo, Adriana Cardoso, E. Y. Ionashiro, A. B. Siqueira","doi":"10.2174/1874842201805010158","DOIUrl":"https://doi.org/10.2174/1874842201805010158","url":null,"abstract":"\u0000 \u0000 The interest in the antioxidant materials increased due to their free radical scavenging properties avoiding various pathologies. Tannic Acid (TA) is known to have high free radical scavenging activity, but its application is still limited.\u0000 This paper had the objective of synthesis, characterization and evaluation of free radical scavenging activity of TA associated with Cu (II) and Zn (II) ions, in a buffered aqueous medium.\u0000 \u0000 \u0000 \u0000 Techniques of FTIR, simultaneous TG-DSC characterized the obtained compounds, and the evaluation of free radical scavenging activity was made using 2,2–diphenyl–1–picrylhydrazyl (DPPH) radical. The FTIR analysis of the compounds showed significant displacement of the main bands in the TA spectrum (νC=O, δO-H, σO-H), suggesting an association of metal ions with the oxygen of the hydroxyl group of TA. TG-DSC curves showed information about the thermal stability, stoichiometry, hydration water, and residues formation.\u0000 \u0000 \u0000 \u0000 The TA association with the metal ions Cu(II) and Zn(II) decreased the antioxidant activity of the molecule significantly, showing that these compounds could be potentially used as pro-oxidant agents.\u0000","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90578575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-30DOI: 10.2174/1874842201805010134
F. Naeem, Humaira Nadeem, A. Muhammad, M. Zahid, A. Saeed
2,4-Thiazolidinedione and its derivatives exhibit a variety of pharmacological activities including antidiabetic, antiviral, antifungal, anti-inflammatory, anti-cancer and aldose reductase inhibitory activities. Keeping in mind the pharmacological potential of 2,4-Thiazolidinedione derivatives as antidiabetic agents, seven arylidene derivatives of 2,4-thiazolidinedione1(a-g)and four corresponding acetic acid derivatives 2(a-d)have been synthesized by a three-step procedure.All the synthesized compounds were characterized by elemental analysis, FTIR,1HNMR, and13CNMR and further screened for their α-amylase inhibitory potential.All the compounds1(a-g)and2(a-d)showed varying degree of α-amylase inhibition, especially compound1c(IC50= 6.59μg/ml),1d(IC50=2.03μg/ml) and1g(IC50= 3.14μg/ml) displayed significantly potent α-amylase inhibition as compared to the standard acarbose (IC50= 8.26μg/ml). None of the acetic acid derivatives of 5-arylidene-2,4-thiazolidinedione showed prominent inhibitory activity. Docking results indicated that the best binding conformation was found inside the active site cleft of enzyme responsible for hydrolysis of carbohydrates.Therefore, it can be concluded that 2,4-thiazolidinedione derivatives can be used as effective lead molecules for the development of α-amylase inhibitors for the management of diabetes.
{"title":"Synthesis, α-Amylase Inhibitory Activity and Molecular Docking Studies of 2,4-Thiazolidinedione Derivatives","authors":"F. Naeem, Humaira Nadeem, A. Muhammad, M. Zahid, A. Saeed","doi":"10.2174/1874842201805010134","DOIUrl":"https://doi.org/10.2174/1874842201805010134","url":null,"abstract":"2,4-Thiazolidinedione and its derivatives exhibit a variety of pharmacological activities including antidiabetic, antiviral, antifungal, anti-inflammatory, anti-cancer and aldose reductase inhibitory activities. Keeping in mind the pharmacological potential of 2,4-Thiazolidinedione derivatives as antidiabetic agents, seven arylidene derivatives of 2,4-thiazolidinedione1(a-g)and four corresponding acetic acid derivatives 2(a-d)have been synthesized by a three-step procedure.All the synthesized compounds were characterized by elemental analysis, FTIR,1HNMR, and13CNMR and further screened for their α-amylase inhibitory potential.All the compounds1(a-g)and2(a-d)showed varying degree of α-amylase inhibition, especially compound1c(IC50= 6.59μg/ml),1d(IC50=2.03μg/ml) and1g(IC50= 3.14μg/ml) displayed significantly potent α-amylase inhibition as compared to the standard acarbose (IC50= 8.26μg/ml). None of the acetic acid derivatives of 5-arylidene-2,4-thiazolidinedione showed prominent inhibitory activity. Docking results indicated that the best binding conformation was found inside the active site cleft of enzyme responsible for hydrolysis of carbohydrates.Therefore, it can be concluded that 2,4-thiazolidinedione derivatives can be used as effective lead molecules for the development of α-amylase inhibitors for the management of diabetes.","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82245252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-30DOI: 10.2174/1874842201805010119
A. Sharma, M. Saxena, Rashmi Sharma
The molar volume, viscosity, specific viscosity, and fluidity of copper surfactant derived from various edible oils in methanol -benzene solvent have been determined at a constant temperature 303 K.The results were used to calculate (CMC), soap complex-solvent interactions and the effect of chain length of the surfactant molecule on various parameters.The conclusions with regard to soap-soap and soap- methanol -benzene interaction have been discussed in terms of well-known Moulik’s and Jones- Dole equations. The effect of surfactant concentration on viscosity of the solution in solvent mixture has been discussed.The observations suggested that the structure breaking effect by the solute on the solvent molecules is more prominent above CMC as compared to below CMC after the formation of the micelles. The vital information plays an important role in various industrial process as well as biological applications.
{"title":"Surface Active Properties and Micellar Features of Copper Soaps Derived from Various Edible Oils","authors":"A. Sharma, M. Saxena, Rashmi Sharma","doi":"10.2174/1874842201805010119","DOIUrl":"https://doi.org/10.2174/1874842201805010119","url":null,"abstract":"The molar volume, viscosity, specific viscosity, and fluidity of copper surfactant derived from various edible oils in methanol -benzene solvent have been determined at a constant temperature 303 K.The results were used to calculate (CMC), soap complex-solvent interactions and the effect of chain length of the surfactant molecule on various parameters.The conclusions with regard to soap-soap and soap- methanol -benzene interaction have been discussed in terms of well-known Moulik’s and Jones- Dole equations. The effect of surfactant concentration on viscosity of the solution in solvent mixture has been discussed.The observations suggested that the structure breaking effect by the solute on the solvent molecules is more prominent above CMC as compared to below CMC after the formation of the micelles. The vital information plays an important role in various industrial process as well as biological applications.","PeriodicalId":39133,"journal":{"name":"Open Medicinal Chemistry Journal","volume":"35 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90882511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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