Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes.

Current molecular biology reports Pub Date : 2017-12-01 Epub Date: 2017-10-19 DOI:10.1007/s40610-017-0074-6

Carolyne Falank, Heather Fairfield, Michaela R Reagan

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Abstract

This review highlights the recent advances in our understanding of adipocyte contributions to carcinogenesis or cancer disease progression for cancers in the bone.

Purpose: In this review, we aim to describe bone marrow adipose tissue and discuss the soluble adipocyte-derived cytokines (adipokines) or endocrine factors, adipocyte-derived lipids, and the actual or putative juxtacrine signaling between bone marrow adipocytes and tumor cells in the bone marrow. This relationship likely affects tumor cell initiation, proliferation, metastasis, and/or drug resistance.

Recent findings: Bone marrow adipose may affect tumor proliferation, drug resistance, or cancer-induced bone disease and hence may be a new target in the fight against cancer.

Summary: Overall, evidence is mixed regarding the role of bone marrow adipose and adipocytes in cancer progression, and more research in this arena is necessary to determine how these bone marrow microenvironmental cells contribute to malignancies in the marrow to identify novel, potentially targetable pathways.

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对骨髓中癌症的思考：脂肪细胞的不利作用。

目的：在这篇综述中，我们旨在描述骨髓脂肪组织，并讨论源自脂肪细胞的可溶性细胞因子（脂肪因子）或内分泌因子、源自脂肪细胞的脂质，以及骨髓脂肪细胞与骨髓肿瘤细胞之间实际或推测的共生信号。这种关系可能会影响肿瘤细胞的启动、增殖、转移和/或耐药性：总结：总体而言，关于骨髓脂肪和脂肪细胞在癌症进展中的作用的证据不一，有必要在这一领域开展更多研究，以确定这些骨髓微环境细胞如何导致骨髓中的恶性肿瘤，从而找出新的、潜在的靶向途径。

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Current molecular biology reports

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