Pub Date : 2024-05-20DOI: 10.1007/s40610-024-00161-0
G. Simsek
{"title":"Immunotherapy in the Treatment of Cancer: Today and Tomorrow","authors":"G. Simsek","doi":"10.1007/s40610-024-00161-0","DOIUrl":"https://doi.org/10.1007/s40610-024-00161-0","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"66 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.1007/s40610-024-00160-1
Aysima Karakus, Beyda Berberogullari
{"title":"Immunotherapy Options for Neuroblastoma: What is on the Horizon?","authors":"Aysima Karakus, Beyda Berberogullari","doi":"10.1007/s40610-024-00160-1","DOIUrl":"https://doi.org/10.1007/s40610-024-00160-1","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"72 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-31DOI: 10.1007/s40610-024-00158-9
Fernanda Ortis, E. Rebelato, A. Carpinelli, F. Abdulkader
{"title":"Insulin Secretion and the β-Cell 102 Years After the Discovery of the Hormone","authors":"Fernanda Ortis, E. Rebelato, A. Carpinelli, F. Abdulkader","doi":"10.1007/s40610-024-00158-9","DOIUrl":"https://doi.org/10.1007/s40610-024-00158-9","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"476 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1007/s40610-023-00155-4
J. R. Connell, R. A. Lea, L. M. Haupt, L. R. Griffiths
Abstract Purpose of Review Mitochondrial DNA (mtDNA) plays an essential role in forensic science, aiding in human identification especially when dealing with degraded DNA samples or cases devoid of paternal family reference samples. Yet, the nuances of isolated populations, shaped by a small number of founders that separate from general populations due to factors such as cultural or geographic differences, and as such, often exhibit very different allele frequencies, pose challenges to its applicability. Recent Findings Recent investigations have determined that ignoring the presence of genetic isolates when performing forensic genetic analysis can introduce significant bias into the results ultimately leading to incorrect match probability estimates, increased false positives or false negatives, miscalculation of familial relationships, ethical and legal concerns, loss of public trust, and mistaken convictions or acquittals. Summary This paper offers a comprehensive review of the challenges and implications for human identification using mtDNA in isolated populations, focusing on population history and social factors; homogeneity of mtDNA; lack of representation in reference databases; and data interpretation and appropriate statistical methods.
{"title":"Mitochondrial DNA Analysis in Population Isolates: Challenges and Implications for Human Identification","authors":"J. R. Connell, R. A. Lea, L. M. Haupt, L. R. Griffiths","doi":"10.1007/s40610-023-00155-4","DOIUrl":"https://doi.org/10.1007/s40610-023-00155-4","url":null,"abstract":"Abstract Purpose of Review Mitochondrial DNA (mtDNA) plays an essential role in forensic science, aiding in human identification especially when dealing with degraded DNA samples or cases devoid of paternal family reference samples. Yet, the nuances of isolated populations, shaped by a small number of founders that separate from general populations due to factors such as cultural or geographic differences, and as such, often exhibit very different allele frequencies, pose challenges to its applicability. Recent Findings Recent investigations have determined that ignoring the presence of genetic isolates when performing forensic genetic analysis can introduce significant bias into the results ultimately leading to incorrect match probability estimates, increased false positives or false negatives, miscalculation of familial relationships, ethical and legal concerns, loss of public trust, and mistaken convictions or acquittals. Summary This paper offers a comprehensive review of the challenges and implications for human identification using mtDNA in isolated populations, focusing on population history and social factors; homogeneity of mtDNA; lack of representation in reference databases; and data interpretation and appropriate statistical methods.","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"25 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.1007/s40610-023-00156-3
Eya Sellami, Gabriel Forato Anhê, Véronique Douard, Fernando Forato Anhê
{"title":"The Gut as a Potential Centerpiece in Fructose-Driven Dysmetabolism","authors":"Eya Sellami, Gabriel Forato Anhê, Véronique Douard, Fernando Forato Anhê","doi":"10.1007/s40610-023-00156-3","DOIUrl":"https://doi.org/10.1007/s40610-023-00156-3","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"113 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135243008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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